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Chrysomycin A (from Streptomyces species) ≥98% (by HPLC)

Supplier: Adipogen
Description: Chrysomycin A is a Topoisomerase II inhibitor.

Small Business Enterprise

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Chrysomycin B (from Streptomyces species) ≥98% (by HPLC)

Supplier: Adipogen
Description: Chrysomycin B is a Topoisomerase II inhibitor.

Small Business Enterprise

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Kirromycin (from Streptomyces collinus) ≥96% (by HPLC)

Supplier: Adipogen
Description: Kirromycin is a member of the elfermycin group.

Small Business Enterprise

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Brefeldin A (from Eupenicillium brefeldianum) ≥97% (by HPLC)

Catalog Number: (102513-584)
Supplier: Adipogen
Description: (+)-Brefeldin A is a protein transport from ER to Golgi inhibitor

Small Business Enterprise


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Anti-4-HNE Mouse Monoclonal Antibody [clone: HNEJ-2]

Catalog Number: (102981-710)
Supplier: Adipogen
Description: Reactive oxygen species (ROS) are involved in lipid peroxidation inside the living bodies, and membrane lipids are one of the major targets of ROS. During the peroxidation process, a variery of aldehydes are formed. 4-hydroxy-2-nonenal (4-HNE) is an alpha, beta unsaturated aldehyde that can be formed by peroxidation of omega-6 unsaturated fatty acids such as linoleic acid and arachidonic acid. Especially, 4-HNE formed inside living body is reported to originate from phospholipid-bound arachidonic acid. 4-HNE may be one of the most reliable biomarker of lipid peroxidation.
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ZnAF-1 DA ≥90% (by HPCE)

Supplier: Adipogen
Description: Suitable for the fluorimetric detection of Zn2+ (after esterase hydrolysis). Spectral data: lambdaex 492nm; lambdaem 515nm in PBS.

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Anti-MG Monoclonal Antibody [clone: 3C]

Catalog Number: (102981-716)
Supplier: Adipogen
Description: Methylglyoxal (MG), an endogenous metabolite that increases in diabetes and is a common intermediate in the Maillard reaction (glycation), reacts with proteins and forms advanced glycation end products (AGE). MG reacts with arginine residue in protein and forms numerous numbers of adducts, such as argpyrimidine.
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Di-tert-butylcyclopentadiene ≥95% (by GC)

Supplier: Adipogen
Description: Building block for synthesis. Frequently used as precursors to di-tert-butylcyclopentadienyl (Cpt) ligand in many sandwich and half sandwich complexes. Di-tert-butylcyclopentadiene reacts with excess potassium tert-butoxide in the presence of elemental selenium to yield cyclopentadienes bridged by two or three selenium atoms through one or two diselenoketal functionalities. It reacts with excess potassium tert-butoxide in the presence of elemental sulfur to yield cyclopentadienes bridged by sulfur atoms via one or two dithioketal functionalities.

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Rat Recombinant Lipocalin 2 (from HEK293 Cells)

Supplier: Adipogen
Description: Lipocalin-2 is an iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development.

Small Business Enterprise

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Betulin derivatives, TargoSet™

Catalog Number: (102981-224)
Supplier: Adipogen
Description: The birch tree has been known for a long time for its healing properties in folk medicine. It can be expected that Betulin an active principle of the birch tree could be used for the treatment of various pathologies. Since, Betulin has three active positions in its structure, secondary hydroxyl group at C-3, primary hydroxyl group at C-28 and a double C-C bonding at C-20, chemical modulations can be performed in order to obtain different types of derivatives. Betulin can be rapidly converted to its „more“ active derivatives, with a wide spectrum of biological and pharmacological activities such as: anti-inflammatory, antimalarial, anti-HIV and antineoplasic.
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Mouse Recombinant Vaspin (from HEK293 cells)

Catalog Number: (102515-020)
Supplier: Adipogen
Description: Vaspin (Visceral adipose tissue-derived serpin; Serpin A12), a serine protease inhibitor (serpin), is an insulin-sensitizing adipocytokine that has been isolated from both visceral and subcutaneous white adipose tissue. Based on recent findings, vaspin is suggested to regulate immune responses and inflammation and was found to be correlated with various metabolic parameters. Vaspin may represent a novel biomarker for obesity and impaired insulin sensitivity and might serve as a new therapeutic target of metabolic syndrome.

Small Business Enterprise


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Imatinib Mesylate

Supplier: Adipogen
Description: Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC(50) values of 0.6µM, 0.1µM and 0.1µM, respectively.

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Human Recombinant IL-10 (from CHO cells)

Supplier: Adipogen
Description: Interleukin-10 (IL-10) is a cytokine produced by activated Th2 cells, B cells, keratinocytes and monocytes/macrophages. In vitro murine and human IL-10 inhibits cytokine synthesis by Th1 cells, natural killer cells and monocytes/macrophages. Several studies have suggested the potential application of IL-10 as an anti-inflammatory agent in the treatment of septic shock and as an immunosuppressive agent in certain T cell mediated autoimmune diseases.

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Mouse Recombinant IL-2 (from CHO Cells)

Supplier: Adipogen
Description: Interleukin-2 (IL-2) is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells, and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils, and induces mononuclear cells to secrete IFN-gamma and TNF-alpha and -beta. Moreover, studies have shown that IL-2 is required for activation-induced apoptosis, an important hemeostatic mechanism in the immune system, which is involved in the maintenance of peripheral tolerance to self-antigens.

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Human Recombinant CD278 (from CHO Cells)

Supplier: Adipogen
Description: CD278, also called inducible costimulator (ICOS) or CRP1 (CD28-related protein-1), is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. ICOS is expressed on most CD45RO+ cells. ICOS expression is upregulated within approximately 24-48 hours of activation on Th primed cells. B7-H2, a member of the B7 family of costimulatory ligands, has been identified as the ICOS ligand. The B7-H2/ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation.

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Calphostin C

Supplier: Adipogen
Description: Potent and highly specific cell permeable protein kinase C (PKC) inhibitor. The inhibition of PKC is light-dependent. PKA, PKG, DAG kinase, phospholipase D1 and D2, myosin light chain kinase and c-Src inhibitor. Anticancer compound. Inhibits cell proliferation and strongly induces apoptosis in vitro. Inducer of endoplasmic reticulum ER-stress. Shown to directly and potently block L-type Ca channels. Calphostin C specifically inhibits contraction-stimulated glucose transport but not insulin-stimulated glucose transport in skeletal muscle. Wnt/beta-catenin/lef-1 signaling inhibitor. beta-catenin/TCF antagonist. Inhibits Wnt-activated genes in a dose-dependent fashion

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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* ATTN: California Customers may require additional documentation as part of the CA Health & Safety Code. Products that fall under this regulation will be placed on a mandatory 21-day hold after documentation is received. VWR will not lift restrictions for residential shipping addresses.

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The original product is no longer available. The replacement shown is available.
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