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Catalog Number: (102513-264)

Supplier: Adipogen

Description: Human CD80 (B7-1) is a costimulatory ligand for CD28 and CD152 (CTLA-4). CD80 is expressed on activated B cells.

Catalog Number: (102513-332)

Supplier: Adipogen

Description: Human CD270 (Herpes Virus Entry Mediator; TNFRSF14; ATAR; LIGHTR; TR2) is a 36kDa type I membrane protein that has been found on a broad range of lymphoid tissues. Its ligands include the TNF ligand family members LTalpha and LIGHT and the CD28/Ig superfamily member BTLA.

Catalog Number: (102513-320)

Supplier: Adipogen

Description: CD271 (p75NTR; TNFRSF16; p75(NTR); Gp80-LNGFR; NGFR) is a type I transmembrane protein, expressed by many cell types including neurons, Schwann cells, mesenchymal stem/stromal cells, follicular dendritic cells and melanocytes. The extracellular portion contains four TNFR-Cys repeats that form the binding domain for its ligands, (NGF, BDNF, NTF3 and NTF4). The intracellular portion of CD271 contains a death domain, which interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9, to promote cell apoptosis and to regulate cell differentiation and neurogenesis.

Catalog Number: (102513-284)

Supplier: Adipogen

Description: Human CD54 (ICAM-1) mediates cell adhesion by binding to the integrins CD11a/CD18 (LFA-1) and to CD11b/CD18 (Mac-1). CD54 expression on resting peripheral blood leukocytes is weak but is upregulated on activated T and B lymphocytes and on monocytes.

Supplier: Adipogen

Description: Pseurotin A is an antibiotic which shows nematicidal activity.

Catalog Number: (102513-346)

Supplier: Adipogen

Description: CD127 (IL-7Ra) is the specific receptor component for the cytokine interleukin -7 (IL-7). It is found on a wide variety of hematopoietic cell types including B cell precursors and the majority of T cells. Its expression levels are decreased on T cells following activation. CD127 can dimerize with CD132 (IL-2Rgamma) to form a high affinity IL-7 receptor. CD127 engagement is necessary for T cell development in humans.

Supplier: Adipogen

Description: Interleukin-4 (IL-4) is a cytokine produced by type 2 helper T cells, the Th2 cells. These cells tends to make a specific set of lymphokines including IL-4, IL-5, IL-6, IL-10, IL-13, IL-3 and GM-CSF and fail to produce IL-2, IFN-gamma, and lymphotoxin (TNF-beta). In addition, mast cells can produce IL-4. IL-4 exerts numerous effects on various hematopoietic cell types. On B cells, IL-4 promotes immunoglobulin class switching to IgE and IgG1 isotypes and upregulates MHC class II and CD23 expression. IL-4 promotes survival, growth, and differentiation of both T and B lymphocytes, mast cells and endothelial cells. In addition, IL-4 inhibits the production of TNF, IL-1, and IL-6 by macrophages.

Catalog Number: (102513-902)

Supplier: Adipogen

Description: The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. TIM-1 (T cell-immunoglobulinmucin; also KIM-1 and HAVcr-1) is a 100 kDa, type I transmembrane glycoprotein member of the TIM family of immunoglobulin superfamily molecules. There are two cytoplasmic alternate splice forms of TIM1. One is a long (359 aa) kidney form termed TIM-1b, and one is a short (334 aa) liver form termed TIM-1a. TIM-1, important for asthma and allergy, is preferentially expressed on T-helper 2 (Th2) cells and functions as a potent costimulatory molecule for T cell activation.

Catalog Number: (102512-066)

Supplier: Adipogen

Description: Human CD16 is a low affinity receptor for complexed IgG and occurs in two distinct forms, as a glycosyl phosphatidyl inositol (GPI) anchored protein in granulocytes and as an integral membrane protein on NK cells and macrophages.

Catalog Number: (102512-060)

Supplier: Adipogen

Description: Human CD15 is expressed by neutrophils, eosinophils and monocytes. Antibodies in this cluster recognize a common terminal pentasaccharide found on cell surface glycoproteins and glycolipids.

Catalog Number: (102512-052)

Supplier: Adipogen

Description: Human CD14 is strongly expressed on myelomonocyte lineage cells including monocytes, macrophages and a subset of granulocytes. CD14 is a high affinity receptor for complexes of lipopolysaccharide and lipopolysaccharide binding protein. A soluble form of CD14 also binds to LPS and LBP.

Catalog Number: (102512-134)

Supplier: Adipogen

Description: Human CD22 expression is restricted to normal Ig+ mature B cells and neoplastic B cells. CD22 is a transmembrane glycoprotein of 140kDa with a predicted adhesion molecule function.

Catalog Number: (102512-118)

Supplier: Adipogen

Description: Human CD21 is a receptor for complement fragments C3d, C3dg or ic3D and also EBV. CD21 is also a ligand for CD23 and plays a role in IgE synthesis.

Catalog Number: (102512-036)

Supplier: Adipogen

Description: Human CD13 is a zinc-binding aminopeptidase-N enzyme expressed on the surface of myeloid cells. IL-4 will upregulate expression of CD13 which may play an anti-inflammatory role.

Catalog Number: (102511-974)

Supplier: Adipogen

Description: Human CD49b is an integrin alpha2 subunit that forms a heterodimer with beta1 integrin and functions as an adhesion molecule.

Catalog Number: (102511-958)

Supplier: Adipogen

Description: Human CD8 is a heterodimeric protein consisting of an alpha and beta chain, each about 33kDa. CD8 is expressed on most thymocytes and on about one third of peripheral blood T cells. CD8 is a co-receptor involved in antigen recognition and binds to the alpha2 and alpha3 domain of MHC Class I molecules.