You Searched For: ADIPOGEN CORP MS

Supplier: Adipogen

Description: New class of highly photostable, water soluble fluorescent labels with large Stoke's shift, high QY in aqueous media and pH tolerance. Major disadvantage: rel. low extinction coefficient.

Supplier: Adipogen

Description: Class of highly photostable, water soluble fluorescent labels with large Stoke′s shift, high QY in aqueous media and pH tolerance. Relatively low extinction coefficient (Epsilon∼ <gt/>20,000 in EtOH).

Supplier: Adipogen

Description: N-Hexadecanoyl-L-homoserine lactone is a small diffusible signaling molecule and is a member of N-acyl-homoserine lactone family. N-acylhomoserine lactones (AHL) are involved in quorum sensing, controlling gene expression, and cellular metabolism. C16-HSL is a lipophilic, long acyl side-chain bearing AHL, produced by the LuxI AHL synthase homolog SinI involved in quorum-sensing signaling in S. meliloti, a nitrogen-fixing bacterial symbiont of certain legumes. C16-HSL is the most abundant AHL produced by the proteobacterium R. capsulatus and activates genetic exchange between R. capsulatus cells. It tends to localize in relatively lipophilic cellular environments of bacteria and cannot diffuse freely through the cell membrane. The long-chain N-acylhomoserine lactones may be exported from cells by efflux pumps or may be transported between communicating cells by extracellular outer membrane vesicles.

Supplier: Adipogen

Description: Stable pyridinium salt of o-iodoxybenzoic acid (PIBX) is a convenient substitute of o-iodoxybenzoic acid (IBX) as an oxidant. PIBX is safer, has neutral properties behaves as an equivalent to IBX in the oxidation of alcohols to ketones or aldehydes in polar solvents and provides higher oxidation rate in THF due to better solubility.

Supplier: Adipogen

Description: Heterocyclic iodane with catalytic activity in the hydrolytic cleavage of reactive phosphates, phosphonates and carboxylates. Used as catalyst for the micellar cleavage of activated esters and phosphates and shown to be powerful reagent for the cleavage of phosphates in an aqueous cetyltrimethylammonium chloride (CTAC) micellar medium.

Supplier: Adipogen

Description: Rhodamine 6G is a highly fluorescent hydrophilic pH-sensitive dye. It is often used as a tracer dye within water to determine the rate and direction of flow and transport. Rhodamine dyes are used extensively in biotechnology applications such as fluorescence microscopy, flow cytometry, fluorescence correlation spectroscopy and ELISA. The dye has a remarkably high photostability and high fluorescence quantum yield. Used as a laser dye and potential mitochondrial probe. The lasing range of the dye is 555 to 585 nm with a maximum at 566 nm. Useful in Pgp efflux assays and has been used to characterize kinetics of MRP1-mediated efflux. Spectral data: lambdaex 528 nm| lambdaem 551 nm (in MeOH).

Supplier: Adipogen

Description: Monomer of aurofusarin. Mycotoxin. Anticancer and antimycobacterial compound in vivo. Moderate tyrosinase inhibitor. Anti-estrogenic.

Supplier: Adipogen

Description: Indole alkaloid. Monoamine oxidase inhibitor (MAOI). Antiepileptic (anticonvulsant) compound. Inhibitor of platelet aggregation and thromboxane A2 synthesis. Weak antifungal and antituberculosis activity. Useful as lead structure for potent antifungal substances.

Supplier: Adipogen

Description: Nucleoside analog. Cytotoxic. DNA, RNA and protein synthesis inhibitor. Shows anticancer activity. Anti-mycobacterial. Has tuberculostatic activity. Antifungal activity. Antiviral (anti-Herpes). Adenosine deaminase inhibitor. Can be used to analyze structure determinants of DNA that are recognized by DNA repair enzymes, to locate triple helices at G-C sequences or as an universal base, which can bind to all four of the nucleosides of DNA.

Supplier: Adipogen

Description: Tripyrrolic pigment like prodigiosin. Antimalarial agent. Apoptosis inducer. Anticancer agent with multiple modes of action. Immunosuppressant in non-toxic concentrations. Bone resorption inhibitor. Antiulcer agent.

Supplier: Adipogen

Description: Actinomycin X2 is an anti-tumor and anti-viral antibiotic.

Supplier: Adipogen

Description: Borrelidin is a bacterial, protozoan and mammalian threonyl-tRNA synthetase (THrRS) inhibitor.

Supplier: Adipogen

Description: Cytochalasan alkaloid, derivative of chaetoglobosin A . Mycotoxin. Phytotoxin.

Catalog Number: (102988-926)

Supplier: Adipogen

Description: Natural cytochalasin derivative. Antiviral. Inhibitor of HIV-1 protease. Antifungal activity.

Supplier: Adipogen

Description: Fibroblast growth factor 21 (FGF-21) is a member of the fibroblast growth factor family and has been identified as an important regulator of energy metabolism connecting nutrition, growth, reproduction and longevity. FGF-21 lacks the heparin-binding domain of most FGF proteins, allowing its secretion. FGF-21 is abundantly expressed in adipose tissues, liver and pancreas. In adipose tissue, FGF-21 promotes glucose uptake and oxidation and in liver it replenishes on fasting the tissues with fuel on low nutritional supply. It also induces lipolysis and ketogenesis. FGF-21 acts through FGF receptors (FGFR) associated with the auxiliary protein beta-Klotho. Recently, FGF-21 has been reported to interact directly with the brain circadian clock to coordinate activity and reproduction as part of the adaptation to fasting. Due to its multiple functions of normalizing glucose, lipid and energy homeostasis, FGF-21 represents an attractive novel therapy for type 2 diabetes mellitus and obesity.

Supplier: Adipogen

Description: Neuregulin-4 (Nrg4) belongs to a small family of EGF-like (EGFL) domain-containing proteins that are synthesized as transmembrane precursors and undergo proteolytic cleavage. The EGF-like domain (aa 5-46) of Nrg4 (aa 1-53) directly binds to the receptors ErbB3 and 4. Nrg4 is a cold induced adipokine, highly expressed in adipose tissues and enriched in brown fat. It is increased during brown adipocyte differentiation and reduced in rodent and human obesity. It promotes neurite outgrowth and protects against diet-induced insulin resistance and hepatic steatosis through attenuating hepatic lipogenic signaling. This hepatic effect of Nrg4 is mediated by ErbB3 and ErbB4 signaling that negatively regulates de novo lipogenesis mediated by LXR and SREBP1c. This effect of Nrg4 on fatty liver and insulin resistance could lead to the development of Nrg4 as an effective therapeutic biological for the treatment of NAFLD and type 2 diabetes. GST-Nrg4 (aa 1-53) recombinant protein has been shown to mimic the effect of endogenous secreted Nrg4 on liver lipogenesis.