You Searched For: ADIPOGEN CORP MS

Catalog Number: (102987-418)

Supplier: Adipogen

Description: Antibiotic

Supplier: Adipogen

Description: May be used as a fluorescent dye in nucleic acid analytical research applications.

Catalog Number: (102987-558)

Supplier: Adipogen

Description: Widespread fungal pentaketide. Weak antibacterial, antifungal and antiviral activity. Specific inhibitor of human DNA polymerase lambda. Weak antigerminative activity.

Supplier: Adipogen

Description: Fluorescent labelling.

Supplier: Adipogen

Description: N,N-dimethyl-6-propionyl-2-naphthylamine (prodan) has both an electron-donor and an electron-acceptor substituent, resulting in a large excited-state dipole moment and extensive solvent polarity-dependent fluorescence shifts. When prodan is incorporated into membranes, their fluorescence spectra are sensitive to the physical state of the surrounding phospholipids. In membranes, prodan appears to localize at the surface, although Fourier transform infrared measurements indicate some degree of penetration into the lipid interior. Excited-state relaxation of prodan is sensitive to the nature of the linkage between phospholipid hydrocarbon tails and the glycerol backbone. Tubulin and its hydrophobic surfaces have been probed with the enviroment-sensitive probes prodan. Prodan is also used for the generation of peroxy-oxalate chemiluminescence with H2O2.

Supplier: Adipogen

Description: Fluorinated fluorescent dye. Increased resistance to photobleaching and higher quantum yields makes it a superior fluorescent dye. Pacific Blue dyes yield conjugates that are strongly fluorescent, even at neutral pH. Spectral data: Extinction 403nm/Emmission 455nm. The amine-reactive succinimidyl ester derivative can be used to create bright blue-fluorescent bioconjugates with excitation/emission maxima ~410/455 nm that are excitable by the 405 nm spectral line of the blue diode (violet) laser.

Supplier: Adipogen

Description: Fluorescein-diacetate-5-isothiocyanate has a lambdaex of 497nm and a lambdaem of 517nm in 0.1 M phosphate pH 7.0.

Supplier: Adipogen

Description: Unnatural amino acid derivative. Pharmacological tool and potential chiral building block used as an internal standard for amino acid analysis. Suitable reagent used for the differentiation of beta-N-methylamino-L-alanine from the diamino acids by using HPLC-FD, UHPLC-UV, UHPLC-MS, and triple quadrupole tandem mass spectrometry (UHPLC-MS/MS). Used in the quantification of neurotoxin beta-N-methylamino-L-alanine (BMAA) in seafood. It has been found to inhibit GABA transaminase (ABAT), producing elevated levels of GABA and to have an antitumor activity.

Supplier: Adipogen

Description: Antibiotic

Supplier: Adipogen

Description: Fluorescent marker used extensively in microscopy studies. Can be used in photoluminometric immunoassays for the formation of conjugates with immunoreactants by fluorescent energy transfer.

Supplier: Adipogen

Description: Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Ganglioside GM1 is a major sialoglycolipid of neuronal membranes that modulates calcium homeostasis and which is important for neuronal plasticity and repair mechanisms. It binds to cholera toxin B subunit, resulting in stimulation of adenylyl cyclase in a wide variety of cell types. After cholera toxin binds to membrane associated Monosialoganglioside GM1, the A subunit of cholera toxin is translocated to the cell interior, where it catalyzes the ADP ribosylation of the membrane associated Gs subunit of adenylyl cyclase. In addition, binding of cholera toxin to monosialoganglioside GM1 causes translocation of NF-kappaB and activation of dendritic cells. E. coli heat-labile enterotoxin (LT) is structurally and functionally similar to cholera toxin and binds GM1 as well. GM1 has also been shown to improve Parkinson's disease symptoms and slow it's progression.

Supplier: Adipogen

Description: Fluorogenic substrate for measuring the chymotrypsin-like peptidase activity of the 20S proteasome. Excitation: 345nm. Emission: 445nm. This substrate is useful for inhibitor screening and kinetic analysis.

Catalog Number: (102988-486)

Supplier: Adipogen

Description: Fluorogenic substrate for measuring the chymotrypsin-like peptidase activity of the 20S proteasome. Fluorogenic substrate for calpain and papain. Peptide substrate for Ti protease from E.coli. Excitation: 360nm. Emission: 460nm. This substrate is useful for inhibitor screening and kinetic analysis.

Supplier: Adipogen

Description: Potent platinum-based antineoplastic agent with wide spectrum anticancer activity. Anticancer compound. Forms inter- and intrastrand DNA adducts/crosslinks, consequently blocking DNA replication and transcription and inducing cell death. Shows antitumor activity in cisplatin resistant cell lines. Shows better biochemical, pharmacological and cytotoxic properties than cisplatin (Prod. No. AG-CR1-3590) and carboplatin (Prod. No. AG-CR1-3591). Apoptosis inducer. Targets other proteins and enzymes. Anticancer activity and antitumor specificity depends on selective uptake through human organic cation transporters 1 (OCT1) and OCT2. Neurotoxic profile depends on organic cation transporter 2 (OCT2) uptake.

Catalog Number: (102981-536)

Supplier: Adipogen

Description: CD279 (Programmed Cell Death Protein 1; PD-1) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T cells, B cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T cell proliferation and production of IL-1, IL-4, IL-10 and IFN-gamma. In addition, CD279 ligation also inhibits BCR mediated signaling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases.

Supplier: Adipogen

Description: Interleukin-4 (IL-4) is a cytokine produced by type 2 helper T cells, the Th2 cells. These cells tends to make a specific set of lymphokines including IL-4, IL-5, IL-6, IL-10, IL-13, IL-3 and GM-CSF and fail to produce IL-2, IFN-gamma, and lymphotoxin (TNF-beta). In addition, mast cells can produce IL-4. IL-4 exerts numerous effects on various hematopoietic cell types. On B cells, IL-4 promotes immunoglobulin class switching to IgE and IgG1 isotypes and upregulates MHC class II and CD23 expression. IL-4 promotes survival, growth, and differentiation of both T and B lymphocytes, mast cells and endothelial cells. In addition, IL-4 inhibits the production of TNF, IL-1, and IL-6 by macrophages.