You Searched For: ADIPOGEN CORP MS

Catalog Number: (102512-288)

Supplier: Adipogen

Description: Human CD37 is a member of the tetraspan family of cell surface molecules that apparantly are involved in signal transduction or transporter system complexes. CD37 is strongly expressed on B lymphocytes (sIg-positive) and weakly on T cells, neutrophils and monocytes. Expression of CD37 disappears during B cell development at the plasma cell stage.

Catalog Number: (102512-298)

Supplier: Adipogen

Description: Human CD38 is a type II transmembrane glycoprotein with bifunctional ectoenzyme activity catalyzing both synthesis and hydrolysis of cyclic ADP ribose. CD38 is involved in lymphocyte activation and adhesion to endothelium and has been identified as a counter-receptor of CD31.

Catalog Number: (102513-400)

Supplier: Adipogen

Description: CD4 binds to MHC Class II expressed by antigen presenting cells, facilitating T cell receptor signaling.

Catalog Number: (102513-358)

Supplier: Adipogen

Description: Human CD272 (BTLA; B and T Lymphocyte Attenuator) is a member of the immunoglobulin superfamily and has sequence homology to PD-1 and CTLA-4. It is expressed on T and B lymphocytes and other hemopoetic lineages. Engagement of this molecule by its ligand CD270 (HVEM) can downregulate activated T and B cell responses. CD272 levels on antigen specific CD8+ T cells have been reported to decrease in viral specific, but not melanoma specific activated lines. Polymorphism of the CD272 molecule has been linked to rheumatoid arthritis.

Catalog Number: (102513-362)

Supplier: Adipogen

Description: Human CD27 is a lymphocyte specific member of the TNF receptor family and is found primarily on peripheral blood T cells and on a subpopulation of B cells and NK cells. The ligand for CD27 is CD70, which is a member of the TNF ligand superfamily.

Catalog Number: (102513-374)

Supplier: Adipogen

Description: Human CD86 (B7-2) is a costimulating ligand for CD28 and CD152 (CTLA-4). CD86 is expressed on activated B cells and blood monocytes.

Catalog Number: (102513-382)

Supplier: Adipogen

Description: Human CD86 (B7-2) is a costimulating ligand for CD28 and CD152 (CTLA-4). CD86 is expressed on activated B cells and blood monocytes.

Catalog Number: (102513-404)

Supplier: Adipogen

Description: CD4 binds to MHC Class II expressed by antigen presenting cells, facilitating T cell receptor signaling.

Catalog Number: (102513-380)

Supplier: Adipogen

Description: Recombinant muIg control protein was engineered to be a negative control for muIg containing fusion proteins.

Catalog Number: (102513-504)

Supplier: Adipogen

Description: Solid

Supplier: Adipogen

Description: Lysolipin I is a glycopeptide synthesis inhibitor.

Supplier: Adipogen

Description: White to off-white solid

Catalog Number: (102513-512)

Supplier: Adipogen

Description: Cytostatic

Catalog Number: (102513-896)

Supplier: Adipogen

Description: Interleukin-27 (IL-27) is a heterodimeric group 2 receptor ligand molecule that belongs to the IL-6/IL-12 family of long type I cytokines. It is composed of EBI3 (EBV-induced gene 3), a 34 kDa glycoprotein that is related to the p40 subunit of IL-12 and IL-23, and p28, the cloned 28 kDa glycoprotein that is related to the p35 chain of IL-12. IL-27 is expressed by monocytes, endothelial cells and dendritic cells. IL-27 binds to and signals through a heterodimeric receptor complex composed of WSX1 (TCCR) and gp130. Evidence suggests IL-27 interacts only with WSX-1. IL-27 has both anti- and proinflammatory properties. As an antiinflammatory, IL-27 seems to induce a general negative feedback program that limits T and NK-T cell activity. At the onset of infection, IL-27 induces an IL-12 receptor on naïe CD4+ T cells, making them susceptible to subsequent IL-12 activity (and possible Th1 development). Notably, IL-12 family cytokines are both induced and inhibited by bacterial products. Microbes promote IL-27 secretion through TLR4, and also block IL-27 production via C5a induction.

Catalog Number: (102513-884)

Supplier: Adipogen

Description: Interleukin-21 (IL-21) is a key factor in the transition between innate and adaptive immune responses secreted by activated T cells. The IL-21 receptor (IL-21R) is expressed in lymphoid tissue, in particular by NK, B, T and dendritic cells, macrophages and endothelial cells. Recent evidence suggests that IL-21 plays a supportive role in the proliferation of T and B cells and influences the cytolytic activity of natural killer cells. IL-21 has been shown to up-regulate genes associated with innate immunity and to inhibit the differentiation of naïve T helper cells. IL-21 specifically inhibits IFN-gamma production from developing TH1 cells and is preferentially expressed by TH2 cells. Furthermore IL-21 has been identified as a growth and survival factor for human myeloma cells. IL-21/IL-21R interactions have a unique role in sequentially activating both innate and adaptive immune responses against poorly immunogenic tumors, leading to tumor rejection that is perforin dependent but IFN-gamma independent.

Supplier: Adipogen

Description: FGF-19 is involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. FGF-19 plays an important role in brain development during embryogenesis. FGF-19 binds only to FGF receptor 4 (FGFR4). Activity requires the presence of KLB.