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EasySep™ Human Extracellular Vesicle (CD9) Positive Selection Kit

Catalog Number: (MSPP-17894)

Supplier: STEMCELL Technologies

Description: Fast and easy isolation of human extracellular vesicles using immunomagnetic positive selection.

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Anti-TRA-1-60 Mouse Monoclonal Antibody [clone: TRA-1-60R] (PE)

Supplier: STEMCELL Technologies

Description: Mouse monoclonal IgM antibody against human, rhesus, rabbit TRA160 (podocalyxin), PE-conjugated.

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EasySep™ Mouse MDSC (CD11b+Gr1+) Isolation Kit

Catalog Number: (MSPP-19867)

Supplier: STEMCELL Technologies

Description: Immunomagnetic isolation of untouched myeloid-derived suppressor cells (CD11b+Gr1+).

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Anti-CD43 Mouse Monoclonal Antibody [clone: CD43-10G7] (PE)

Supplier: STEMCELL Technologies

Description: Mouse monoclonal IgG1 antibody against human CD43, PE-conjugated.

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Anti-CD66b Mouse Monoclonal Antibody [clone: G10F5] (FITC)

Catalog Number: (MSPP-60086FI1)

Supplier: STEMCELL Technologies

Description: Mouse monoclonal IgM antibody against human, chimpanzee CD66b, FITCconjugated.

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Human Recombinant MCP-1 (CCL2)

Supplier: STEMCELL Technologies

Description: Monocyte chemotactic protein-1 (MCP-1), also known as CCL2, is a member of the CC family of chemokines. The protein is primarily induced by platelet-derived growth factor (PDGF) gene (Cochran et al.). The biological effects of MCP-1 are mediated via the specific G-protein-coupled receptor CCR2 which in turn activates signal transduction pathways leading to monocyte transmigration (Sozzani et al.). Migration of monocytes from the bloodstream across the vascular endothelium is required for routine immunological surveillance of tissues, as well as other immunomodulatory effects. MCP-1 is produced by a variety of cell types, including fibroblasts and endothelial, epithelial, smooth muscle, mesangial, astrocytic, monocytic, and microglial cells, which are important for antiviral responses in the peripheral circulations and in tissues (Cushing et al.; Deshmane et al.). MCP-1 plays a role in physiological processes such as neurogenesis, neuroprotection, and neurotransmission and has important implications in neurological disorders such as multiple sclerosis and Alzheimer’s disease, in which it is produced during neuroinflammation at the sites of lesions (Conductier et al.).

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HPV16 (E7) Peptide Pool

Catalog Number: (MSPP-100-1394)

Supplier: STEMCELL Technologies

Description: Stimulating T cells with HPV16 (E7) Peptide Pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. HPV16 (E7) Peptide Pool is a lyophilized mixture of 22 peptides from protein E7 of human papillomavirus type 16 (HPV16) consisting of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 - 98 on protein E7. E7 is an oncoprotein that binds and mediates degradation of the retinoblastoma tumor suppressor protein pRB (Gonzalez et al.). E7 together with E6 demonstrated the ability to immortalize human keratinocytes in vitro, which likely has significance for HPVs oncogenic potential (Hawley-Nelson et al.). Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.

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Human Recombinant BDNF, ACF

Supplier: STEMCELL Technologies

Description: Brain-derived neurotrophic factor (BDNF), like nerve growth factor (NGF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4), is a member of the NGF family of neurotrophins, which are required for the differentiation and survival of specific neuronal subpopulations in both the central and the peripheral nervous systems (Minichiello and Klein; Minichiello et al.). BDNF binds with high affinity to the TRKB kinase receptor, and activates AKT and ERK pathways (Mattson et al.). It is expressed in hippocampus, cortex, and synapses of the basal forebrain. BDNF acts as a survival factor for human embryonic stem cells when plated on either feeder cells or Corning® Matrigel® (Pyle et al.). BDNF regulates synaptic transmission and plasticity at adult synapses in the central nervous system, contributes to adaptive neuronal responses including long-term potentiation, long-term depression, certain forms of short-term synaptic plasticity, as well as homeostatic regulation of neuronal excitability (Reichardt). It also has a role in neurogenesis by promoting survival and growth of dorsal root ganglion cells, and hippocampal and cortical neurons (Binder and Scharfman). BDNF, together with glial cell-derived neurotrophic factor (GDNF) and other supplements, is commonly used to differentiate human pluripotent stem cell (hPSC)-derived neural progenitor cells into neurons (Brafman). This product is animal component-free.

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Human Recombinant EGFR

Catalog Number: (MSPP-781711006)

Supplier: STEMCELL Technologies

Description: Epidermal growth factor receptor (EGFR) is a type I transmembrane protein and receptor tyrosine kinase. EGFR has been shown to bind to some members of the EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, epiregulin, heparin-binding EGF, and neuregulin-2α. EGFR ligand binding induces homodimerization, as well as heterodimerization of EGFR with ErbB2 or with ligand-activated ErbB3 or ErbB4 (Schlessinger). Dimerization results in kinase activation, phosphorylation, and cell signaling, mediated primarily through MEK/ERF and AKT pathways (Navlonic et al.). EGFR signaling has been shown to regulate cell proliferation, differentiation, motility, and apoptosis. Elevated levels of EGFR have been correlated with carcinogenesis (Maihle et al.). Protein contains a His-residue tag at the carboxyl end of the polypeptide chain.

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MesenCult™ ACF Plus Umbilical Cord Culture Kit

Catalog Number: (MSPP-100-0234)

Supplier: STEMCELL Technologies

Description: Animal component-free medium and substrate for derivation and expansion of human mesenchymal stromal cells from umbilical cord tissue.

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