You Searched For: STEMCELL Technologies

Supplier: STEMCELL Technologies

Description: Rat monoclonal IgG1, antibody against mouse IFN-gamma, Biotin-conjugated.

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Catalog Number: (MSPP-60023)

Supplier: STEMCELL Technologies

Description: Rat monoclonal IgG2a antibody against mouse, toad CD8a, unconjugated.

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Supplier: STEMCELL Technologies

Description: Rat monoclonal IgG2a, kappa isotype control antibody, unconjugated.

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Supplier: STEMCELL Technologies

Description: Stromal cell-derived factor 1 alpha (SDF-1α) is a member of the CXC group of chemokines that binds to the G-protein coupled receptor, CXCR4, to regulate migration, proliferation, differentiation, and survival of many cell types including hematopoietic stem cells, B cells, and T cells. It is produced by bone marrow stromal cells, osteoblasts, endothelial cells, and neuronal cells. SDF-1α was first identified as the pre-B-cell growth-stimulating factor (PBSF) in the mouse bone marrow-derived stromal cell line, PA6, in the growth of B cell precursors (Hayashi <i>et al.</i>). SDF-1α primarily regulates cell motility during development and adulthood, including the homing of hematopoietic stem cells and neutrophils to fetal bone marrow during ontogeny (Ara <i>et al.</i> 2003a) and the recruitment of endothelial progenitor cells from bone marrow during angiogenesis in adulthood (Zheng <i>et al.</i>). In addition to its role in hematopoiesis, the SDF-1α/CXCR4 signaling pathway is also essential for the homing of primordial germ cells to gonads (Ara <i>et al.</i> 2003b), the migration of granule cells in the cerebellum during neurogenesis (Zou <i>et al.</i>), and the migration of breast cancer cells to sites of metastasis (Muller <i>et al.</i>).

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Supplier: STEMCELL Technologies

Description: Nerve growth factor (NGF)-beta is a prototypical member of the neurotrophin family and has a role in the survival and growth of neural cells, regulating cell growth, promoting differentiation into neurons, and neuron migration. The beta subtype of NGF is biologically active in comparison to the alpha-2 and gamma-2 subtypes. NGF-beta in its secreted form can bind to tyrosine kinase A (TrkA) receptor with high affinity and to p75 (NTR) with low affinity (Levi and Alemà; Sofroniew <i>et al.</i>). NGF has been shown to possess pro-inflammatory and pro-fibrogenic properties (Micera <i>et al.</i>). It has also been shown that overexpression of NGF-beta promotes differentiation of bone marrow mesenchymal stem cells into neurons through regulation of AKT and MAPK pathways (Yuan <i>et al.</i>).

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Catalog Number: (MSPP-60069AD)

Supplier: STEMCELL Technologies

Description: Mouse monoclonal IgM, kappa isotype control antibody, Alexa Fluor® 488­conjugated.

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Catalog Number: (MSPP-60083PE)

Supplier: STEMCELL Technologies

Description: Mouse monoclonal IgG1 antibody against human, chimpanzee CD22, PE­conjugated.

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Catalog Number: (MSPP-60071AD)

Supplier: STEMCELL Technologies

Description: Mouse monoclonal IgG2a, kappa isotype control antibody, Alexa Fluor® 488-conjugated.

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Supplier: STEMCELL Technologies

Description: Rat monoclonal IgG2a antibody against mouse CD4, PE-conjugated.

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Catalog Number: (MSPP-781821006)

Supplier: STEMCELL Technologies

Description: Fibroblast growth factor 5 (FGF-5) is a secreted, heparin-binding member of the FGF subfamily. FGFs possess broad mitogenic and cell survival activities and are expressed during embryonic development. FGF-5 is expressed in the mesenchyme, skeletal muscles, central nervous systems, and hair follicles. FGF-5 promotes cell differentiation and proliferation by binding FGF receptor 1 and FGF receptor 2 (FGFR1 and FGFR2, respectively). FGF-5 plays an important regulatory role in skeletal muscle development. FGF-5 has also been identified in neurons of the limbic system, especially those of the olfactory bulb and pyramidal cells of the hippocampus (Haub and Goldfarb).

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Catalog Number: (MSPP-100-0994)

Supplier: STEMCELL Technologies

Description: A cell-permeable calcium dye that exhibits fluorescence upon increasing Ca2+ concentrations.

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Catalog Number: (MSPP-100-0923)

Supplier: STEMCELL Technologies

Description: For detection of active caspase-3 in mammalian cells undergoing apoptosis - 100 tests.

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Catalog Number: (MSPP-781651006)

Supplier: STEMCELL Technologies

Description: Interferon gamma-inducible protein (IP) 10 or CXCL10 is a member of the CXC chemokine family. It binds CXCR3 activating ERK1/2, p38/MAPK, JNK, and PI3-kinase/AKT signaling pathways, inducing intracellular calcium influx, DNA synthesis, cell proliferation, and chemotaxis. IP-10 regulates innate and adaptive immune responses by affecting the function of activated T cells, natural killer cells, inflammatory dendritic cells, macrophages, and B cells. IP-10 is produced by leukocytes, activated neutrophils, eosinophils, monocytes, epithelial cells, endothelial cells, fibroblasts, and keratinocytes in response to IFN-gamma. IP-10 has been implicated in a wide range of diseases, including infectious diseases and chronic inflammatory and autoimmune diseases, as well as in tumor formation (Liu <i>et al.</i>).

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Catalog Number: (MSPP-10989)

Supplier: STEMCELL Technologies

Description: Supplement for the maturation of human monocyte-derived dendritic cells.

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Catalog Number: (MSPP-100-0215)

Supplier: STEMCELL Technologies

Description: Serum-free culture medium kit for differentiation of human PSCs to atrial cardiomyocytes.

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Catalog Number: (MSPP-17965)

Supplier: STEMCELL Technologies

Description: Immunomagnetic negative selection kit.

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