You Searched For: STEMCELL Technologies

Catalog Number: (MSPP-05965)

Supplier: STEMCELL Technologies

Description: Medium for the differentiation of human skeletal muscle progenitor cells (myoblasts) into myotubes.

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Catalog Number: (MSPP-01995)

Supplier: STEMCELL Technologies

Description: For detection and measurement of human immunoglobulin M.

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Catalog Number: (MSPP-60143)

Supplier: STEMCELL Technologies

Description: Rabbit polyclonal antibody against human, mouse SHIP2, unconjugated.

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Catalog Number: (MSPP-60146)

Supplier: STEMCELL Technologies

Description: Mouse monoclonal IgG1 antibody against human CD326 (EpCAM), unconjugated.

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Catalog Number: (MSPP-60147)

Supplier: STEMCELL Technologies

Description: Mouse monoclonal IgG1 antibody against human epithelial cells, unconjugated.

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Catalog Number: (MSPP-03234)

Supplier: STEMCELL Technologies

Description: Methylcellulose-based medium without cytokines (including EPO) for mouse cells.

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Catalog Number: (MSPP-100-0190)

Supplier: STEMCELL Technologies

Description: Cell culture medium for establishment and maintenance of human colorectal cancer organoids.

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Supplier: STEMCELL Technologies

Description: Granulocyte-macrophage colony-stimulating factor (GM-CSF) promotes the proliferation and differentiation of hematopoietic progenitor cells and the generation of neutrophils, eosinophils, and macrophages. In synergy with other cytokines such as stem cell factor, IL-3, erythropoietin, and thrombopoietin, it also stimulates erythroid and megakaryocyte progenitors (Barreda <i>et al.</i>). GM-CSF is produced by multiple cell types, including stromal cells, Paneth cells, macrophages, dendritic cells (DCs), endothelial cells, smooth muscle cells, fibroblasts, chondrocytes, and Th1 and Th17 T cells (Francisco-Cruz <i>et al.</i>). The receptor for GM-CSF (GM-CSFR) is composed of two subunits: the cytokine-specific α subunit (GMRα; CD116) and the common subunit βc (CD131) shared with IL-3 and IL-5 receptors (Broughton <i>et al.</i>). GM-CSFR is expressed on hematopoietic cells, including progenitor cells and immune cells, as well as non-hematopoietic cells. Recombinant human GM-CSF (rhGM-CSF) promotes the production of myeloid cells of the granulocytic (neutrophils, eosinophils and basophils) and monocytic lineages <i>in vivo</i>. It has been tested for mobilization of hematopoietic progenitor cells and for treating chemotherapy-induced neutropenia in patients. GM-CSF is able to stimulate the development of DCs that ingest, process, and present antigens to the immune system (Francisco-Cruz <i>et al.</i>). This product is animal component-free.

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Supplier: STEMCELL Technologies

Description: Heparin-binding epidermal growth factor (EGF)-like growth factor (HBEGF) is a member of the EGF family (Nishi and Klagsbrun). HBEGF promotes blastocyst adhesion to the uterine wall (Iwamoto and Mekada). It also plays a role in smooth muscle cell hyperplasia and brain injury (Nishi and Klagsburn). HBEGF produced by CD4+ T cells promotes wound healing by stimulating migration and proliferation of keratinocytes, fibroblasts, and smooth muscle cells (Blotnick <i>et al.</i>). It binds to EGFR, ErbB4, ErbB2, and ErbB3, activating the PI3K/AKT signaling cascade (Iwamoto and Mekada). HBEGF is produced in a variety of cells, where it contributes to physiological and pathological processes. HBEGF is overexpressed in ovarian, breast, gastric, colorectal, pancreatic, and endometrial cancers, which likely contributes to pathogenesis (Miyata <i>et al.</i>).

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Supplier: STEMCELL Technologies

Description: Receptor activator of nuclear factor kappa-B ligand (RANKL) is a member of the tumor necrosis factor (TNF) superfamily (Anderson <i>et al.</i>). Cytokines in the TNF superfamily are involved in a variety of long-term cellular activities such as differentiation, proliferation, and cell death (MacEwan). RANKL is a type II homotrimeric transmembrane protein expressed in both a membrane-bound and secreted form (Ikeda <i>et al.</i>). RANKL binds to the receptor activator of nuclear factor kappa-B (RANK). Upon binding to its receptor, RANKL activates the AKT signaling pathway (Moon <i>et al.</i>). Osteoprotegerin (OPG) may also bind RANKL, and this binding competes with RANKL-RANK binding (Lacey <i>et al.</i>). RANKL is involved in osteoclastogenesis (Lacey <i>et al.</i>; Yasuda <i>et al.</i>) and T cell activation (Wong <i>et al.</i>).

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Supplier: STEMCELL Technologies

Description: Indian hedgehog (IHH) is one of three proteins in the hedgehog family which includes sonic hedgehog and desert hedgehog. Hedgehog proteins are important signaling molecules, acting through patched and smoothened receptors. During embryonic development, they are expressed in the fetal lung, gut, stomach, liver, kidney, and pancreas. IHH is strongly expressed in cartilage and regions of developing bone, and its signaling regulates growth and differentiation of bone tissue (Marigo <i>et al.</i>; Valentini <i>et al.</i>; St-Jacques <i>et al.</i>). IHH is also involved in yolk sac vasculogenesis, indicating a role in the differentiation of epiblast cells into endothelial and red blood cells (Byrd <i>et al.</i>). IHH induces the expression of parathyroid hormone-related peptide (PTHrP), which negatively regulates IHH during chondrocyte differentiation and proliferation (Vortkamp <i>et al.</i>).

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Supplier: STEMCELL Technologies

Description: Interferon-alpha (IFN-α) is a type I interferon, produced by virus infected cells, and is released as a soluble factor to initiate antiviral responses (Isaacs and Lindenmann). IFN-α2 is the most potent IFN-α used in fundamental research and in most clinical applications. The best known IFN-α2 subvariants, 2A and 2B, differ by only one or two amino acids at positions 23 and/or 34 of the mature protein (von Gabain <i>et al.</i>). Type I IFNs exert potent antitumor activity by increasing the cytotoxic activity of NK and T cells, as well as inhibiting the proliferation of cancer cells (Paul <i>et al.</i>). Additionally, it has been shown that proinflammatory IFN-α modulates the function of B cells in patients with systemic lupus erythematosus (Chang <i>et al.</i>) and pegylated form of IFN-α 2A and 2B has implications in the treatment of Hepatitis C (Foster <i>et al.</i>).

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Supplier: STEMCELL Technologies

Description: Biopreservation reagent for cells and tissues.

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Supplier: STEMCELL Technologies

Description: Mouse monoclonal IgG2b, antibody against human, chimpanzee, CD45RA, PE-conjugated.

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Catalog Number: (MSPP-09701)

Supplier: STEMCELL Technologies

Description: Serum-free medium and supplement for the measurement of drug toxicity on erythroid cells.

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Catalog Number: (MSPP-09300)

Supplier: STEMCELL Technologies

Description: 10% BSA in Iscove's MDM.

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