You Searched For: STEMCELL Technologies

Catalog Number: (MSPP-17531)

Supplier: STEMCELL Technologies

Description: Density gradient medium.

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Catalog Number: (MSPP-100-0784)

Supplier: STEMCELL Technologies

Description: cGMP, human T cell activation and expansion reagent.

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Catalog Number: (MSPP-100-1336)

Supplier: STEMCELL Technologies

Description: Interferon alpha 1 (IFNA1) belongs to the type 1 interferon family of cytokines, which bind interferon alpha receptors (IFNAR; composed of IFNAR1 and IFNAR2 subunits) that are involved in interferon-induced JAK-STAT signaling (Shemesh <i>et al.</i>). Interferons have inhibitory effects on viral replication and pathogenesis, and studies have found that IFN alpha can prevent the spread of herpes simplex virus (HSV) (Mikloska and Cunningham), and human immunodeficiency virus (HIV) (George and Mattapallil). Pegylated forms of IFN alpha are currently approved for the treatment of chronic hepatitis B (Woo <i>et al.</i>). IFN alpha also displays anti-tumor effects by regulating cell growth and proliferation, and it is used in the treatment of different cancers (Tagliaferri <i>et al.</i>). Interferons display alpha-helical structures with four helices forming an antiparallel alpha-helix bundle (Walter). This protein contains a His-residue tag at the carboxyl end of the polypeptide chain. For consistency and reproducibility across your applications, interferon alpha 1 from STEMCELL comes lyophilized with ≥90% purity, specific activity EC50 ≤40 to 200 pg/ml, and LAL analysis verification ensuring endotoxin levels are ≤1.0 EU/μg protein.

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Catalog Number: (MSPP-781651006)

Supplier: STEMCELL Technologies

Description: Interferon gamma-inducible protein (IP) 10 or CXCL10 is a member of the CXC chemokine family. It binds CXCR3 activating ERK1/2, p38/MAPK, JNK, and PI3-kinase/AKT signaling pathways, inducing intracellular calcium influx, DNA synthesis, cell proliferation, and chemotaxis. IP-10 regulates innate and adaptive immune responses by affecting the function of activated T cells, natural killer cells, inflammatory dendritic cells, macrophages, and B cells. IP-10 is produced by leukocytes, activated neutrophils, eosinophils, monocytes, epithelial cells, endothelial cells, fibroblasts, and keratinocytes in response to IFN-gamma. IP-10 has been implicated in a wide range of diseases, including infectious diseases and chronic inflammatory and autoimmune diseases, as well as in tumor formation (Liu <i>et al.</i>).

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Supplier: STEMCELL Technologies

Description: Immunomagnetic isolation of mouse naïve CD4+ T cells.

Catalog Number: (MSPP-18002)

Supplier: STEMCELL Technologies

Description: The EasySep™ Easy 50 magnet is designed for cell separation procedures using selected EasySep™ reagents when processing a large number of cells (up to 4×10⁹ cells).

Catalog Number: (MSPP-18001)

Supplier: STEMCELL Technologies

Description: The EasySep™ 'The Big Easy' magnet is designed for cell separation procedures using EasySep™ reagents when processing a large number of cells, or when using RoboSep™.

Supplier: STEMCELL Technologies

Description: Immunomagnetic isolation of untouched human plasmacytoid dendritic cells (pDC)

Supplier: STEMCELL Technologies

Description: Interleukin 2 (IL-2) is a monomeric cytokine that was originally identified as a T cell growth factor (Gaffen and Liu). It binds to heterotrimeric receptors consisting of CD25, CD122, and CD132. Upon binding, it activates JAK3-, STAT5-, and AKT-dependent signaling pathways, which results in cellular proliferation and survival (Ma <i>et al.</i>). The majority of IL-2 is secreted by activated CD4+ and CD8+ T cells, although B cells and dendritic cells were found to produce IL-2 in small amounts. IL-2 downregulates immune responses to prevent autoimmunity during thymic development, influences the development of CD4+CD25+ regulatory T cells, and affects development of follicular helper T cells. IL-2 also controls inflammation by inhibiting Th17 differentiation (Banchereau <i>et al.</i>). High IL-2 levels in serum are associated with progression of scleroderma, rheumatoid arthritis, and gastric and non-small cell lung cancer, though no known disease can be directly attributed to the lack or excess of IL-2 (Gaffen and Liu).

Supplier: STEMCELL Technologies

Description: Immunomagnetic positive selection of CD90.2+ cells from mouse splenocytes or other tissues.

Catalog Number: (MSPP-19868)

Supplier: STEMCELL Technologies

Description: Immunomagnetic isolation of untouched mouse epithelial cells

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Supplier: STEMCELL Technologies

Description: 7‐AAD (7‐Aminoactinomycin D) is a fluorescent cell viability dye which is excluded from live cells with intact membranes but penetrates dead or damaged cells and binds to double‐stranded DNA with high affinity by intercalating between GC base pairs.

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Supplier: STEMCELL Technologies

Description: Column-free immunomagnetic positive selection of human CD33+ and CD66b+ cells for HLA analysis.

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Supplier: STEMCELL Technologies

Description: Immunomagnetic positive selection of human CD138+ cells from whole blood and bone marrow (e.g. normal or malignant plasma cells for multiple myeloma research).

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Supplier: STEMCELL Technologies

Description: For digestion of native collagen fibrils.

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Catalog Number: (MSPP-01995)

Supplier: STEMCELL Technologies

Description: For detection and measurement of human immunoglobulin M.

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