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Catalog Number: (MSPP-60044BT)
Supplier: STEMCELL Technologies
Description: Mouse monoclonal IgG1 antibody against human, rhesus, chimpanzee CD73, biotin-conjugated.

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Supplier: STEMCELL Technologies
Description: Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD41, FITC-conjugated.

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Catalog Number: (MSPP-60006AZ1)
Supplier: STEMCELL Technologies
Description: Rat monoclonal IgG2a antibody against mouse CD19, APC-conjugated.

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Supplier: STEMCELL Technologies
Description: Interleukin 3 (IL-3) is a species-specific pleiotropic cytokine that promotes the survival and proliferation of pluripotent hematopoietic stem cells and lineage-committed progenitor cells and their differentiation into mature cells of most lineages, including basophils, neutrophils, eosinophils, macrophages, dendritic cells, erythrocytes, and megakaryocytes (Yang <i>et al.</i>; Dorssers <i>et al.</i>; Broughton <i>et al.</i>). IL-3 is produced by activated T cells and has a physiological role in inflammation and allergies by promoting the secretion of inflammatory mediators such as histamine, IL-4, and IL-6 by basophils and eosinophils (Broughton <i>et al.</i>). The IL-3 receptor consists of a unique alpha subunit (CD123) and a beta common subunit (βc or CD131) that is shared with the receptors for IL-5 and GM-CSF, and is the principal signal transduction subunit for these cytokines. IL-3 binding to the heterodimeric receptor activates JAK/STAT, MAPK, and PI3K signaling pathways (Woodcock <i>et al.</i>).

Catalog Number: (MSPP-15272HLA)
Supplier: STEMCELL Technologies
Description: Immunodensity isolation of untouched myeloid cells for lineage-specific chimerism analysis.


Supplier: STEMCELL Technologies
Description: Human Interleukin 4 (IL-4) is important for immune responses to helminth infection as well as in allergic responses (Olpihant <i>et al.</i>). The IL-4 receptor consists of a heterodimer of IL-4Ra and common gamma chain. IL-4 receptor engagement leads to the activation of JAK1/3 and the recruitment of STAT6 and IRS1/2 (Nelms <i>et al.</i>). IL-4 drives immunoglobulin class switching in B cells (to IgE, IgG4), mast cell hyperplasia, mucus production, and the differentiation of naïve T cells into T helper type 2 (Th2) cells, which produce IL-4, IL-5, IL-10, and IL-13 (Bao <i>et al.</i>; Olpihant <i>et al.</i>; Nelms <i>et al.</i>). In addition to Th2 T cells, IL-4 is produced by CD4+ NK T cells, γ/δ T cells, activated basophils, eosinophils, and mast cells. IL-4 consists of 130 amino acids with a predicted molecular weight of 15.1 kDa. Human IL-4 does not cross-react with mouse cells (Park <i>et al.</i>). This product is animal component-free.

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Catalog Number: (MSPP-04444)
Supplier: STEMCELL Technologies
Description: Pre-aliquoted methylcellulose-based medium with recombinant cytokines for human cells. 24×3 ml vials.

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Supplier: STEMCELL Technologies
Description: Insulin-like growth factor 2 (IGF-II) is a polypeptide that belongs to the family of insulin-like growth factors that are similar in molecular structure to proinsulin. IGF-II binding to IGF-I receptor activates a signaling cascade via the MAPK and PI3K pathways. IGF-II affects growth, differentiation, and survival of cells in a variety of tissues during embryonic development. It stimulates proliferation and migration of primary lymphatic endothelial cells, and induces lymphangiogenesis (Guvakova).

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Catalog Number: (MSPP-60024AZ)
Supplier: STEMCELL Technologies
Description: Mouse monoclonal IgG1 antibody against mouse, rat, guinea pig CD90/CD90.1, APC-conjugated.

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Catalog Number: (MSPP-100-1593)
Supplier: STEMCELL Technologies
Description: Mouse monoclonal antibody against mouse CD45.1, PE-conjugated.

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Supplier: STEMCELL Technologies
Description: Complete kit for CD34+ cells from cord blood.

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Catalog Number: (MSPP-100-0020)
Supplier: STEMCELL Technologies
Description: Maturation kit for the generation of microglia from human ES and iPS cell-derived microglia precursors.

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Catalog Number: (MSPP-60039)
Supplier: STEMCELL Technologies
Description: Mouse monoclonal IgG1 antibody against human, mouse CD105 (endoglin), unconjugated.

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Supplier: STEMCELL Technologies
Description: Macrophage colony-stimulating factor (M-CSF) is a homodimeric glycoprotein growth factor that regulates proliferation and differentiation of myeloid hematopoietic progenitors to mononuclear phagocytic cell lineages, including monocytes, macrophages, and osteoclasts. M-CSF is a crucial factor for the development of tissue-resident macrophages in most tissues (Ginhoux andamp; Jung). It is required for the maturation and activation of monocytes and macrophages, and regulates inflammatory responses in conjunction with other stimuli such as IFN-γ, LPS, and IL-4 (Murray <i>et al.</i>). M-CSF is also required for bone resorption by osteoclasts, and is involved in the development and regulation of placenta, mammary gland, and brain. M-CSF is produced by monocytes, fibroblasts, osteoclasts, stromal cells, endothelial cells, and tumor cells (Chockalingam andamp; Ghosh). M-CSF exerts its biological effects by signaling through a receptor tyrosine kinase (CSF-1R or M-CSF-R) encoded by the c-fms proto-oncogene (Hamilton). CSF-1R shares similar structural features with other growth factor receptors, including the stem cell factor (SCF) receptor, platelet-derived growth factor receptor (PDGF-R), and Flt3/Flk-2 receptor tyrosine kinase. Stimulation of the CSF-1R upon binding to M-CSF activates MAPK, PI3K, and PLCγ signaling pathways (Chockalingam andamp; Ghosh). Human and mouse M-CSF sequences are highly conserved both at nucleotide and amino acid levels (80% homology; DeLamarter <i>et al.</i>). This product is animal component-free.

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Supplier: STEMCELL Technologies
Description: Heparin-binding epidermal growth factor (EGF)-like growth factor (HBEGF) is a member of the EGF family (Nishi and Klagsbrun). HBEGF promotes blastocyst adhesion to the uterine wall (Iwamoto and Mekada). It also plays a role in smooth muscle cell hyperplasia and brain injury (Nishi and Klagsburn). HBEGF produced by CD4+ T cells promotes wound healing by stimulating migration and proliferation of keratinocytes, fibroblasts, and smooth muscle cells (Blotnick <i>et al.</i>). It binds to EGFR, ErbB4, ErbB2, and ErbB3, activating the PI3K/AKT signaling cascade (Iwamoto and Mekada). HBEGF is produced in a variety of cells, where it contributes to physiological and pathological processes. HBEGF is overexpressed in ovarian, breast, gastric, colorectal, pancreatic, and endometrial cancers, which likely contributes to pathogenesis (Miyata <i>et al.</i>). This product is animal component-free.

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Catalog Number: (MSPP-100-1334)
Supplier: STEMCELL Technologies
Description: Macrophage inflammatory protein-4 (MIP-4) plays a role in adaptive and innate immune responses, acting as a chemoattractant for T and B lymphocytes, and natural killer cells (Krohn <i>et al.</i>). MIP-4 can also induce immune tolerance through its effects on dendritic cells and macrophages (Azzaoui <i>et al.</i>, Schraufstatter <i>et al.</i>). In breast cancer, MIP-4 has been shown to promote the invasiveness and metastasis of cancer cells in vivo by binding PITPNM3 (Chen <i>et al.</i>).This small cytokine belongs to the chemokine family found only in primates. Based on amino acid sequence, MIP-4 is closely related to MIP-1 alpha (CCL3) and MIP-1 beta (CCL4) (Liang <i>et al.</i>). MIP-4 is produced by antigen-presenting immune cells including dendritic cells, macrophages, and monocytes (Lieshout <i>et al.</i>). For consistency and reproducibility across your applications, macrophage inflammatory protein-4 from STEMCELL comes lyophilized with ≥95% purity, and is verified by LAL analysis to ensure endotoxin levels are ≤1.0 EU/μg protein.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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