You Searched For: STEMCELL Technologies

Catalog Number: (MSPP-60044BT)

Supplier: STEMCELL Technologies

Description: Mouse monoclonal IgG1 antibody against human, rhesus, chimpanzee CD73, biotin-conjugated.

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Supplier: STEMCELL Technologies

Description: Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD41, FITC-conjugated.

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Catalog Number: (MSPP-60006AZ1)

Supplier: STEMCELL Technologies

Description: Rat monoclonal IgG2a antibody against mouse CD19, APC-conjugated.

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Supplier: STEMCELL Technologies

Description: Interleukin 3 (IL-3) is a species-specific pleiotropic cytokine that promotes the survival and proliferation of pluripotent hematopoietic stem cells and lineage-committed progenitor cells and their differentiation into mature cells of most lineages, including basophils, neutrophils, eosinophils, macrophages, dendritic cells, erythrocytes, and megakaryocytes (Yang <i>et al.</i>; Dorssers <i>et al.</i>; Broughton <i>et al.</i>). IL-3 is produced by activated T cells and has a physiological role in inflammation and allergies by promoting the secretion of inflammatory mediators such as histamine, IL-4, and IL-6 by basophils and eosinophils (Broughton <i>et al.</i>). The IL-3 receptor consists of a unique alpha subunit (CD123) and a beta common subunit (βc or CD131) that is shared with the receptors for IL-5 and GM-CSF, and is the principal signal transduction subunit for these cytokines. IL-3 binding to the heterodimeric receptor activates JAK/STAT, MAPK, and PI3K signaling pathways (Woodcock <i>et al.</i>).

Catalog Number: (MSPP-15272HLA)

Supplier: STEMCELL Technologies

Description: Immunodensity isolation of untouched myeloid cells for lineage-specific chimerism analysis.

Supplier: STEMCELL Technologies

Description: Human Interleukin 4 (IL-4) is important for immune responses to helminth infection as well as in allergic responses (Olpihant <i>et al.</i>). The IL-4 receptor consists of a heterodimer of IL-4Ra and common gamma chain. IL-4 receptor engagement leads to the activation of JAK1/3 and the recruitment of STAT6 and IRS1/2 (Nelms <i>et al.</i>). IL-4 drives immunoglobulin class switching in B cells (to IgE, IgG4), mast cell hyperplasia, mucus production, and the differentiation of naïve T cells into T helper type 2 (Th2) cells, which produce IL-4, IL-5, IL-10, and IL-13 (Bao <i>et al.</i>; Olpihant <i>et al.</i>; Nelms <i>et al.</i>). In addition to Th2 T cells, IL-4 is produced by CD4+ NK T cells, γ/δ T cells, activated basophils, eosinophils, and mast cells. IL-4 consists of 130 amino acids with a predicted molecular weight of 15.1 kDa. Human IL-4 does not cross-react with mouse cells (Park <i>et al.</i>). This product is animal component-free.

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Catalog Number: (MSPP-04444)

Supplier: STEMCELL Technologies

Description: Pre-aliquoted methylcellulose-based medium with recombinant cytokines for human cells. 24×3 ml vials.

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Supplier: STEMCELL Technologies

Description: Insulin-like growth factor 2 (IGF-II) is a polypeptide that belongs to the family of insulin-like growth factors that are similar in molecular structure to proinsulin. IGF-II binding to IGF-I receptor activates a signaling cascade via the MAPK and PI3K pathways. IGF-II affects growth, differentiation, and survival of cells in a variety of tissues during embryonic development. It stimulates proliferation and migration of primary lymphatic endothelial cells, and induces lymphangiogenesis (Guvakova).

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Catalog Number: (MSPP-60024AZ)

Supplier: STEMCELL Technologies

Description: Mouse monoclonal IgG1 antibody against mouse, rat, guinea pig CD90/CD90.1, APC-conjugated.

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Catalog Number: (MSPP-100-1593)

Supplier: STEMCELL Technologies

Description: Mouse monoclonal antibody against mouse CD45.1, PE-conjugated.

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Supplier: STEMCELL Technologies

Description: Complete kit for CD34+ cells from cord blood.

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Catalog Number: (MSPP-100-0020)

Supplier: STEMCELL Technologies

Description: Maturation kit for the generation of microglia from human ES and iPS cell-derived microglia precursors.

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Catalog Number: (MSPP-60039)

Supplier: STEMCELL Technologies

Description: Mouse monoclonal IgG1 antibody against human, mouse CD105 (endoglin), unconjugated.

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Supplier: STEMCELL Technologies

Description: Macrophage colony-stimulating factor (M-CSF) is a homodimeric glycoprotein growth factor that regulates proliferation and differentiation of myeloid hematopoietic progenitors to mononuclear phagocytic cell lineages, including monocytes, macrophages, and osteoclasts. M-CSF is a crucial factor for the development of tissue-resident macrophages in most tissues (Ginhoux andamp; Jung). It is required for the maturation and activation of monocytes and macrophages, and regulates inflammatory responses in conjunction with other stimuli such as IFN-γ, LPS, and IL-4 (Murray <i>et al.</i>). M-CSF is also required for bone resorption by osteoclasts, and is involved in the development and regulation of placenta, mammary gland, and brain. M-CSF is produced by monocytes, fibroblasts, osteoclasts, stromal cells, endothelial cells, and tumor cells (Chockalingam andamp; Ghosh). M-CSF exerts its biological effects by signaling through a receptor tyrosine kinase (CSF-1R or M-CSF-R) encoded by the c-fms proto-oncogene (Hamilton). CSF-1R shares similar structural features with other growth factor receptors, including the stem cell factor (SCF) receptor, platelet-derived growth factor receptor (PDGF-R), and Flt3/Flk-2 receptor tyrosine kinase. Stimulation of the CSF-1R upon binding to M-CSF activates MAPK, PI3K, and PLCγ signaling pathways (Chockalingam andamp; Ghosh). Human and mouse M-CSF sequences are highly conserved both at nucleotide and amino acid levels (80% homology; DeLamarter <i>et al.</i>). This product is animal component-free.

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Supplier: STEMCELL Technologies

Description: Heparin-binding epidermal growth factor (EGF)-like growth factor (HBEGF) is a member of the EGF family (Nishi and Klagsbrun). HBEGF promotes blastocyst adhesion to the uterine wall (Iwamoto and Mekada). It also plays a role in smooth muscle cell hyperplasia and brain injury (Nishi and Klagsburn). HBEGF produced by CD4+ T cells promotes wound healing by stimulating migration and proliferation of keratinocytes, fibroblasts, and smooth muscle cells (Blotnick <i>et al.</i>). It binds to EGFR, ErbB4, ErbB2, and ErbB3, activating the PI3K/AKT signaling cascade (Iwamoto and Mekada). HBEGF is produced in a variety of cells, where it contributes to physiological and pathological processes. HBEGF is overexpressed in ovarian, breast, gastric, colorectal, pancreatic, and endometrial cancers, which likely contributes to pathogenesis (Miyata <i>et al.</i>). This product is animal component-free.

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Catalog Number: (MSPP-100-1334)

Supplier: STEMCELL Technologies

Description: Macrophage inflammatory protein-4 (MIP-4) plays a role in adaptive and innate immune responses, acting as a chemoattractant for T and B lymphocytes, and natural killer cells (Krohn <i>et al.</i>). MIP-4 can also induce immune tolerance through its effects on dendritic cells and macrophages (Azzaoui <i>et al.</i>, Schraufstatter <i>et al.</i>). In breast cancer, MIP-4 has been shown to promote the invasiveness and metastasis of cancer cells in vivo by binding PITPNM3 (Chen <i>et al.</i>).This small cytokine belongs to the chemokine family found only in primates. Based on amino acid sequence, MIP-4 is closely related to MIP-1 alpha (CCL3) and MIP-1 beta (CCL4) (Liang <i>et al.</i>). MIP-4 is produced by antigen-presenting immune cells including dendritic cells, macrophages, and monocytes (Lieshout <i>et al.</i>). For consistency and reproducibility across your applications, macrophage inflammatory protein-4 from STEMCELL comes lyophilized with ≥95% purity, and is verified by LAL analysis to ensure endotoxin levels are ≤1.0 EU/μg protein.

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