You Searched For: ADIPOGEN CORP MS

Catalog Number: (102514-524)

Supplier: Adipogen

Description: Tribbles homolog 3 (TRB-3) is a pseudokinase, shown to act as a potent negative regulator of PPAR?, a master regulator of adipocyte differentiation, and to control adipogenesis. It disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. It interacts also with the NF-kappaB transactivator p65 RELA. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells.

Catalog Number: (102514-470)

Supplier: Adipogen

Description: Retinol binding protein 4 (RBP4; RBP) is a 21kDa secreted protein, a member of the lipocalin family and is known as the primary transporter of retinol (vitamin A) to tissues. A recent report revealed RBP4 as an adipokine linking glucose transporter 4 (GLUT4) suppression in adipose tissue to insulin. Elevated human and mouse serum RBP4 levels are associated with insulin resistance and its severity, obesity and certain components of metabolic syndrome. Furthermore, human serum RBP4 levels are closely related to renal function.

Catalog Number: (102514-500)

Supplier: Adipogen

Description: Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30kDa human IL33 is converted by CASP1 to a 18kDa protein. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1(MAPK3)/ERK2(MAPK1), p38(MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.

Catalog Number: (102514-536)

Supplier: Adipogen

Description: ANGPTL4 mainly expressed in endothelial cells (hypoxia-induced). Regulates angiogenesis and modulates tumorgenesis and directly regulates lipid, glucose, and energy metabolism. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage.

Catalog Number: (102514-478)

Supplier: Adipogen

Description: Retinol binding protein 4 (RBP4; RBP) is a 21kDa secreted protein, a member of the lipocalin family and is known as the primary transporter of retinol (vitamin A) to tissues. A recent report revealed RBP4 as an adipokine linking glucose transporter 4 (GLUT4) suppression in adipose tissue to insulin. Elevated human and mouse serum RBP4 levels are associated with insulin resistance and its severity, obesity, and certain components of metabolic syndrome. Furthermore, human serum RBP4 levels are closely related to renal function.

Catalog Number: (102514-676)

Supplier: Adipogen

Description: Repetin is a late epidermal differentiation marker. Repetin is involved in the formation of the cornified cell envelope. It is a multifunctional epidermal matrix protein, which reversibly binds to calcium. Its expression is scattered in the normal epidermis but strong in the acrosyringium, the inner hair root sheat and in the filiform papilli of the tongue.

Catalog Number: (102514-644)

Supplier: Adipogen

Description: CTRP7 belongs to a highly conserved family of adiponectin paralogs.

Catalog Number: (102514-666)

Supplier: Adipogen

Description: TRAM functions in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. It is also involved in IL-1-triggered NF-kappaB activation, functioning upstream of IRAK1, IRAK2, TRAF6 and IKBKB. TRAM physically bridges TLR4 and TICAM-1 and functionally transmits LPS-TRL4 signal to TICAM-1. It is expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle and pancreas.

Catalog Number: (102514-674)

Supplier: Adipogen

Description: Cornulin is a survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines. It attenuates deoxycholic acid (DCA)-induced apoptotic cell death and the release of calcium. In overexpressed oral squamous carcinoma cell lines, cornulin negatively regulates cell proliferation by the induction of G1 arrest.

Catalog Number: (102514-698)

Supplier: Adipogen

Description: Tubulin is the major building block of microtubules. This intracellular cylindrical filamentous structure is present in almost all eukaryotic cells. Microtubules function as structural and mobile elements in mitosis, intracellular transport, flagellar movement, and the cytoskeleton.

Catalog Number: (102514-670)

Supplier: Adipogen

Description: Nod (CARD4) is a cytosolic pattern recognition molecule (PRRs) of the NLR (NOD-like receptor) family. Nod1 is widely expressed by many cell types and is implicated in sensing meso-diaminopimelic acid (meso-DAP)-containing PGN fragments, which are present in most Gramnegative bacteria and certain Gram-positive ones, like the Bacillus species. Upon activation, Nod1 initiates a pro-inflammatory response through NF-kappa signaling and is a key receptors in epithelial cells where it controls infections via the gastrointestinal system. Mutations in Nod1 have been reported to confer susceptibility to several inflammatory disorders including inflammatory bowel disease, atopic eczema and asthma.

Supplier: Adipogen

Description: Jagged-1 is a ligand for multiple Notch receptors and involved in the mediation of Notch signaling. It is involved in cell-fate decisions during hematopoiesis. Is involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Defects in Jagged-1 are the cause of Alagille syndrome type 1 (ALGS1) and tetralogy of Fallot (TOF).

Supplier: Adipogen

Description: FGF-21 (Fibroblast growth factor 21) stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of betaKlotho.

Supplier: Adipogen

Description: The Notch ligand delta-like protein 1 (DLL1) is essential for postnatal arteriogenesis and contributes to tumor progression. DLL1 is involved in differentiation and self-renewal of adipocyte stem cells. Blocks the differentiation of progenitor cells into the B cell lineage while promoting the emergence of a population of cells with the characteristics of a T cell/NK-cell precursor.

Catalog Number: (102511-728)

Supplier: Adipogen

Description: Human T cell receptor (TCR) is a T cell surface expressed heterodimer of alpha/beta or gamma/delta chains. TCR’s recognize antigen peptides bound to MHC molecules forming the basis of antigen specific response by T cells.

Catalog Number: (102511-840)

Supplier: Adipogen

Description: The human CD1 genetic locus consists of five closely related genes. Three of the gene products (CD1a, CD1b and CD1c) have been officially clustered using antibodies and are expressed on cortical thymocytes, a subset of B cells, and on most professional antigen presenting cells. CD1 molecules have a specialized lipid antigen-presenting function.