You Searched For: STEMCELL Technologies

Catalog Number: (MSPP-04564)

Supplier: STEMCELL Technologies

Description: Complete kit for hematopoietic CFU assays.

New Product

Catalog Number: (MSPP-60091)

Supplier: STEMCELL Technologies

Description: Mouse monoclonal IgG1 antibody against human, cynomolgus nestin, unconjugated.

New Product

Supplier: STEMCELL Technologies

Description: Animal component-free and protein-free cryopreservation formulation.

New Product

Supplier: STEMCELL Technologies

Description: Mouse monoclonal IgG1 antibody against human MUC1 (CD227), PE-conjugated.

New Product

Catalog Number: (MSPP-04330)

Supplier: STEMCELL Technologies

Description: Methylcellulose-based medium with EPO for human cells.

New Product

Catalog Number: (MSPP-04444)

Supplier: STEMCELL Technologies

Description: Pre-aliquoted methylcellulose-based medium with recombinant cytokines for human cells. 24×3 ml vials.

New Product

Catalog Number: (MSPP-04531)

Supplier: STEMCELL Technologies

Description: Methylcellulose-based medium with agar-LCM (without EPO) for human cells.

New Product

Catalog Number: (MSPP-05008)

Supplier: STEMCELL Technologies

Description: Serum- and BPE-free medium for expansion of primary human airway epithelial cells.

New Product

Supplier: STEMCELL Technologies

Description: Human Interleukin 4 (IL-4) is important for immune responses to helminth infection as well as in allergic responses (Olpihant <i>et al.</i>). The IL-4 receptor consists of a heterodimer of IL-4Ra and common gamma chain. IL-4 receptor engagement leads to the activation of JAK1/3 and the recruitment of STAT6 and IRS1/2 (Nelms <i>et al.</i>). IL-4 drives immunoglobulin class switching in B cells (to IgE, IgG4), mast cell hyperplasia, mucus production, and the differentiation of naïve T cells into T helper type 2 (Th2) cells, which produce IL-4, IL-5, IL-10, and IL-13 (Bao <i>et al.</i>; Olpihant <i>et al.</i>; Nelms <i>et al.</i>). In addition to Th2 T cells, IL-4 is produced by CD4+ NK T cells, γ/δ T cells, activated basophils, eosinophils, and mast cells. IL-4 consists of 130 amino acids with a predicted molecular weight of 15.1 kDa. Human IL-4 does not cross-react with mouse cells (Park <i>et al.</i>). This product is animal component-free.

New Product

Supplier: STEMCELL Technologies

Description: Immunomagnetic isolation of untouched rat CD8+ T cells

New Product

Catalog Number: (MSPP-01917)

Supplier: STEMCELL Technologies

Description: Substrate for ELISA antibody pair kits.

New Product

Catalog Number: (MSPP-01916)

Supplier: STEMCELL Technologies

Description: Diluent for ELISA samples, standards, and detection antibodies.

New Product

Supplier: STEMCELL Technologies

Description: Human Recombinant Angiotensin-Converting Enzyme 2 (ACE2) Protein, aa18-740, is expressed in HEK293 cells. ACE2 activity results in vasodilation by degrading vasoconstrictor angiotensin II to produce vasodilator angiotensin. Decreased expression of this enzyme is associated with cardiovascular disease and possibly also glomerular injury in diabetic nephropathy. ACE2 contains a peptidase domain at the N-terminus and a single transmembrane helix. ACE2 is also the primary human receptor for the surface spike glycoprotein of SARS-CoV-2 and SARS-CoV. This receptor is expressed in human lung and small intestine epithelia as well as the heart, kidney, and testes. The peptidase domain of ACE2 binds to the protein-binding domain of the S1 protein subunit of the spike protein; this binding results in a cleavage site becoming exposed. Cleavage, or ‘protein priming’, is done by TMPRSS2, a cellular serine protease, and by cathepsins. This cleavage activates the S2 subunit of the spike protein, allowing the fusion of the viral membrane to the host cell membrane. At the carboxy terminus, Human Recombinant ACE2 Protein contains a TEV site and a human IgG1 Fc tag.

New Product

Catalog Number: (MSPP-100-1327)

Supplier: STEMCELL Technologies

Description: Butyrophilin 1A1 (BTN1A1) is a glycoprotein belonging to the butyrophilin (BTN) family which collectively modulates immune responses, through excitatory and inhibitory signals targeting immune cells. Butyrophilins are composed of two extracellular immunoglobulin domains and a transmembrane region, with a conserved B30.2 domain (PRYSPRY) that is present in most members (Malinowska <i>et al.</i>). BTN1A1, along with BTN2A2, has been shown to inhibit the proliferation of CD4+ and CD8+ T cells, modify T cell metabolism, and affect the expression of IL-2 and IFN-γ (Smith <i>et al.</i>). Due to these modulatory effects on T cells, BTN1A1 may have a role in inhibiting the development of autoimmune diseases (Stefferl <i>et al.</i>). BTN1A1 is also expressed in mammary glands and is required for the secretion of milk lipids during lactation (Ogg <i>et al.</i>). This protein contains a His-residue tag at the carboxyl end of the polypeptide chain. For consistency and reproducibility across your applications, Serpin A12 from STEMCELL comes lyophilized with ≥92% purity, and is verified by LAL analysis to ensure endotoxin levels are ≤1.0 EU/μg protein.

New Product

Catalog Number: (MSPP-100-1329)

Supplier: STEMCELL Technologies

Description: Modulate prostaglandin metabolism with 15-hydroxyprostaglandin dehydrogenase (15-PGDH). 15-PGDH catalyzes the reversible oxidation of the 15-hydroxyl group in prostaglandins, resulting in inactivated metabolites (Ensor and Tai), it can act on a variety of prostaglandins as substrates in a NAD+ dependent manner (Cho <i>et al.</i>). As prostaglandins can have a range of effects on cellular processes, 15-PGDH is of considerable importance in drug development. <i>in vitro</i> and <i>in vivo</i> studies suggest 15-PGDH has tumor suppressive activity and is downregulated in certain cancers (Na <i>et al.</i>).15-PGDH belongs to the short-chain dehydrogenases/reductases (SDR) family; its primary structure indicates 20% homology with other SDRs, with some conserved amino acid residues (Krook <i>et al.</i>). This protein contains a His-residue tag at the carboxyl end of the polypeptide chain. For consistency and reproducibility across your applications, apo M from STEMCELL comes lyophilized with ≥ 89% purity.

New Product

Supplier: STEMCELL Technologies

Description: Rat monoclonal IgG2a antibody against mouse CD62L (L-selectin), FITC-conjugated.

New Product