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Product Image-77392-874

Chloromonas augustae Recombinant Channelopsin 1 (from P. pastoris)

Catalog Number: (77392-874)
Supplier: CUBE BIOTECH
Description: Channelrhodopsin 1 is a 7-transmembrane protein that acts as a light-driven cation channel in eukaryotic green algae.
Product Image-77392-820

Nanodisc Rat MSP1D1-His DMPC

Catalog Number: (77392-820)
Supplier: CUBE BIOTECH
Description: Membrane scaffold protein; rat origin.
Product Image-77392-734

Nanodisc MSP1E3D1-His DMPC

Catalog Number: (77392-734)
Supplier: CUBE BIOTECH
Description: This product is a pre-assembled nanodisc. Its intended purpose is to stabilize a cell-free expressed membrane protein.
Product Image-77392-668

Human Recombinant MSP1D1 dH5 (from E. coli)

Supplier: CUBE BIOTECH
Description: Membrane scaffold protein.

Product Image-77392-654

Human Recombinant MSP1D1-His (from E. coli)

Supplier: CUBE BIOTECH
Description: Membrane scaffold protein, human origin.

Product Image-77392-554

AASTY 6-55

Supplier: CUBE BIOTECH
Description: AASTYs (Acrylic acid-co-styrenes) - like AASTY 6-55 - are highly-alternating copolymers, well-suited for generating native lipid nanodiscs. They are a 2022 novel developed series for membrane protein solubilization & stabilization. AASTY 6-55 gets its name from its molecular weight and Acrylic Acid : Styrene Ratio. These varying ratios of acrylic acid to styrene contribute to the hydrophilic properties of our AASTYs. In general, lighter AASTYs, like 6-55 tend to be more aggressive, while heavier AASTYs, such as 11-45 show higher thermodynamic stability.

The exact composition of AASTY copolymers shows different extraction efficiency, depending on the lipid composition of the lipid bilayers being formulated into nanodiscs. As AASTY is made by controlled radical polymerization techniques, the dispersity of polymer molecular weight distribution is low, and the molecular weights are controlled. This means that excess AASTY copolymer can be removed by dialysis after nanodisc formation. Based on previous findings on SMA, it is the expectation that AASTY of different molecular weights will display different rates of nanodisc formation, extraction efficacy, and stability of resulting nanodiscs.

Every membrane protein solubilization needs to undergo a screening process before. The characteristic phospholipid environment surrounding the different membrane proteins in question performs differently well with each polymer. To support you in this process, we offer a handy Screening Kit for AASTYs to test them all. Additionally, we recommend the two following publications if you would like to get further information: Smith et al. 2020 & Timcenko et al. 2022

Product Image-77392-700

Nanodisc Assembly Kit MSP1D1 dH5 POPC

Catalog Number: (77392-700)
Supplier: CUBE BIOTECH
Description: This product is a MSP nanodisc assembly kit. It contains a vial of lyophilized membrane scaffold protein MSP1D1 dh5 and a vial of DMPC or POPC phopshospholipid to assemble a MSP nanodisc.
Image Unavailable-77392-702

Nanodisc Assembly Kit MSP1E3D1-His DMPC

Catalog Number: (77392-702)
Supplier: CUBE BIOTECH
Description: This product is a MSP nanodisc assembly kit. It contains a vial of lyophilized membrane scaffold protein MSP1E3D1 (His-tagged) and a vial of DMPC or POPC phopshospholipid to assemble a MSP nanodisc.
Product Image-77392-694

Nanodisc Assembly Kit MSP1D1 DMPC

Catalog Number: (77392-694)
Supplier: CUBE BIOTECH
Description: This product is a MSP nanodisc assembly kit. It contains a vial of lyophilized membrane scaffold protein MSP1D1 and a vial of DMPC or POPC phopshospholipid to assemble a MSP nanodisc.
Image Unavailable-77392-324

n-Decyl-β-D-maltoside ≥99.5%, Crystallization grade

Supplier: CUBE BIOTECH
Description: Decylmaltoside are well suited for the solubilization, stabilization, and purification of membrane proteins. For screening of the best-suited detergent for a given application, we offer maltosides with chain lengths from C-9 to C-13.

Image Unavailable-77392-560

AASTY 11-55

Supplier: CUBE BIOTECH
Description: AASTYs (Acrylic acid-co-styrenes) - like AASTY 11-55 - are highly alternating copolymers, well-suited for generating native lipid nanodiscs. They are a 2022 novel developed series for membrane protein solubilization & stabilization. AASTY 11-55 is named from its molecular weight and Acrylic Acid : Styrene Ratio. These varying ratios of acrylic acid to styrene contribute to the hydrophilic properties of our AASTYs. In general lighter AASTYs, like 6-45 tend to be more aggressive, while heavier AASTYs, such as 11-55 show higher thermodynamic stability.

The exact composition of AASTY copolymers shows different extraction efficiencies, depending on the lipid composition of the lipid bilayers being formulated into nanodiscs. As AASTY is made by controlled radical polymerization techniques, the dispersity of polymer molecular weight distribution is low, and the molecular weights are controlled. This means that excess AASTY copolymer can be removed by dialysis after nanodisc formation. Based on previous findings on SMA, it is the expectation that AASTY of different molecular weights will display different rates of nanodisc formation, extraction efficacy, and stability of resulting nanodiscs.

Every membrane protein solubilization needs to undergo a screening process before. The characteristic phospholipid environment surrounding the different membrane proteins in question performs differently well with each polymer. To support you in this process we offer a handy Screening Kit for AASTYs to test them all. Additionally, we recommend the two following publications if you would like to get further information: Smith et al. 2020 & Timcenko et al. 2022

Product Image-77392-568

Synthetic Nanodisc Screening Kit MAXI

Catalog Number: (77392-568)
Supplier: CUBE BIOTECH
Description: Synthetic copolymers are capable of solubilizing and stabilizing membrane proteins without the need for detergents. They have the unique capacity to extract the membrane protein of interest while maintaining a near-native environment.
Product Image-77392-492

DIBMA glucosamine in HEPES, PureCube for protein solubilisation

Supplier: CUBE BIOTECH
Description: With diisobutylene-maleic acid (DIBMA), you can directly extract membrane proteins from cells without an intermediate step of detergent solubilization, like with SDS, which would usually interfere with the protein's function. Another advantage of DIBMA as a tool for protein solubilization is the lack of an absorbance maxima at 280 nm. In comparison to SMAs, this would usually interfere with protein quantification, as aromatic amino acids absorb at the same spectrum. PureCube DIBMA is lyophilized from two different buffer solutions (HEPES or TRIS) to ensure a stable pH of 7.5, which is ideal for most protein solubilizations. A good publication to read even more details about DIBMA is Oluwole et al. 2017.

Product Image-77392-998

PureCube Compact Cartridge Co-NTA

Supplier: CUBE BIOTECH
Description: The PureCube Co-NTA Compact cartridge is an IMAC chromatography column prepacked with PureCube Co-NTA resin.

Product Image-77393-442

PureCube 100 Ni-NTA Agarose

Supplier: CUBE BIOTECH
Description: Our PureCube Ni-NTA agarose resins are your best option to purify His-tagged protein using FPLC, Batch spin, or column chromatography.

Product Image-77393-458

PureCube 100 Co-NTA Agarose

Supplier: CUBE BIOTECH
Description: Our PureCube 100 Co-NTA agarose resins are agarose resin beads with a diameter of 100 µm. They are used for the purification of active His-tagged proteins from cells.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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