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Supplier: CUBE BIOTECH
Description: The SMALP products have been developed for biomedical purposes, in particular, for the solubilization of (biological) lipid membranes and isolation & purification of integral membrane proteins.
After solving the SMA + buffer powder in water, the product is ready-to-use. It can primarily used for all cell membrane hosts, including bacteria, yeast, and human cells. After successful solubilization of the membrane protein, the protein can be purified using affinity chromatography. For membrane protein purification we recommend using the Rho1D4-tag. Cube Biotech offers matching products for this purpose.

Catalog Number: (77392-766)
Supplier: CUBE BIOTECH
Description: This product is a pre-assembled nanodisc. Its intended purpose is to stabilize a cell-free expressed membrane protein.


Supplier: CUBE BIOTECH
Description: Sulfo-DIBMA is an electroneutral modification of existing DIBMAs. It does not interfere with charge-sensitive interactions between proteins and lipids. This innovation opens up a wider range of experimental research in terms of charge-sensitive membrane protein processes like protein-protein and protein-lipid interactions. In addition, Sulfo-DIBMA belongs to a new generation of DIBMA’s which are RAFT polymerized. This achieves a reduction in both monomer size and greater monodispersity. With diisobutylene-maleic acid (DIBMA), you can directly extract membrane proteins from cells without an intermediate step of detergent solubilization, like with SDS, which would usually interfere with the protein's function. Another advantage of DIBMA is the lack of an absorbance maxima at 280 nm. SMAs, in comparison, usually interfere with protein quantification, as aromatic amino acids absorb at the same spectrum.
Another significant advantage of Sulfo polymers compared to other polymers is the wide pH range in which they remain stable. The buffer in which the polymer is supplied has a pH of 7.5, but the polymer itself remains stable between pH 4 and pH 10. The special physicochemical properties of Sulfo-DIBMAs make them ideal for cryo-TEM and other downstream applications.
Good publications to find details about Sulfo-DIBMA and Sulfo-SMA are:
Oluwole et al. (2017)
Glueck et al. (2022)
Janson et al. (2022)
Eggenreich et al. (2023)

Supplier: CUBE BIOTECH
Description: PureCube NHS (N-hydroxy succinimide) MagBeads/magnetic beads XL are your best option to couple biomolecules carrying free-standing amine groups.

Supplier: CUBE BIOTECH
Description: PureCube Zn-NTA magnetic beads/MagBeads were developed by Cube Biotech for His-tag protein purification.

Supplier: CUBE BIOTECH
Description: Our PureCube octyl agarose resin is a suspension of purification beads for Hydrophobic Interaction Chromatography (HIC).

Supplier: CUBE BIOTECH
Description: PureCube NHS (N-hydroxy succinimide) agarose XL resin is your best option to couple biomolecules carrying free-standing amine groups.

Supplier: CUBE BIOTECH
Description: HighSpec Rho1D4 MagBeads XL is a suspension of 90 µm magnetic agarose beads coupled to an anti-Rho1D4 antibody.

Supplier: CUBE BIOTECH
Description: HiCap StrepTactin® Compact Cartridge is a FPLC-ready column that is pre-packed with our PureCube HiCap StrepTactin® agarose resin.

Supplier: CUBE BIOTECH
Description: Phosphocholines, or Fos-cholines, are a novel class of detergents that is well suited for the solubilization, stabilization, and purification of membrane proteins. For screening of the best-suited detergent for a given application, we offer Fos-cholines with chain lengths from C-9 to C-16.

Supplier: CUBE BIOTECH
Description: PureCube Ni-NTA agarose resins are your best option to purify His-tagged protein using FPLC, Batch spin, or column chromatography.

Supplier: CUBE BIOTECH
Description: HighSpec Rho1D4 Agarose resin is a suspension of 40 µm agarose beads, coupled to an anti-Rho1D4 antibody. It is meant for protein purification assays of the highest possible purity, exploiting the specificity of an antibody to its antigen.

Catalog Number: (77392-712)
Supplier: CUBE BIOTECH
Description: This product is a pre-assembled nanodisc. Its intended purpose is to stabilize a cell-free expressed membrane protein.


Catalog Number: (77392-706)
Supplier: CUBE BIOTECH
Description: This product is a MSP nanodisc assembly kit. It contains a vial of lyophilized membrane scaffold protein MSP2N2 (His-tagged) and a vial of DMPC or POPC phopshospholipid to assemble a MSP nanodisc.


Supplier: CUBE BIOTECH
Description: PureCube 100 Ni-INDIGO agarose resin is a unique development by Cube Biotech for His-tag protein purifications of the highest quality.

Supplier: CUBE BIOTECH
Description: PolyHunter agarose was developed for the depletion of synthetic polymers used in solubilization steps.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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The original product is no longer available. The replacement shown is available.
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