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Supplier: Peprotech

Description: Interleukin-35 is a glycosylated, disulfide-linked, heterodimeric protein consisting of the p35 subunit from IL-12 (IL-12α) and the β subunit from IL-27 (EBI3). IL-35 can be expressed by regulatory T-cells (Tregs), macrophages, and certain trophoblast and dendritic cells. It is induced in response to inflammation, and generally acts as an inflammation suppressor. IL-35 suppresses inflammation by exerting multiple activities, including the induction of regulatory T-cells and the suppression of Th17 cells. Recombinant Human IL-35 produced from

Supplier: Peprotech

Description: IL-34 is a homodimeric cytokine that is expressed in a range of tissues that include spleen, heart, brain, liver, kidney, lung, ovary, thymus, testis, small intestine, prostate and colon. IL-34 is a ligand for colony-stimulating factor-1 receptor (CSF1R), which also binds to CSF-1. It specifically binds CD14+ monocytes, promotes survival and proliferation of human peripheral blood monocytes, and stimulates macrophage colony formation by human bone marrow cells. IL-34, like human CSF-1, stimulates phosphorylation of MAPK1/ERK2 and MAPK3/ERK1. Recombinant Human IL-34 is a 52.5 kDa homodimeric glycoprotein consisting of 460 amino acid residues, including a C-terminal His-Tag.

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Supplier: Peprotech

Description: Produced from sera of rabbits immunized with highly pure Recombinant Human BCA-1 (CXCL13). Anti­Human BCA-1 (CXCL13)­specific antibody was purified by affinity chromatography and then biotinylated.

Supplier: Peprotech

Description: Produced from sera of goats immunized with highly pure Recombinant Human IL-12. Anti­Human IL-12­specific antibody was purified by affinity chromatography and then biotinylated.

Supplier: Peprotech

Description: Produced from sera of rabbits immunized with highly pure Recombinant Human MCP-4 (CCL13). Anti­Human MCP-4 (CCL13)­specific antibody was purified by affinity chromatography employing an immobilized Human MCP-4 matrix.

Supplier: Peprotech

Description: Produced from sera of rabbits immunized with highly pure Recombinant Human NAP-2 (CXCL7). Anti­Human NAP-2 (CXCL7)­specific antibody was purified by affinity chromatography employing an immobilized Human NAP-2 matrix.

Supplier: Peprotech

Description: Produced from sera of rabbits immunized with highly pure Recombinant Human PF-4 (CXCL4). Anti­Human PF-4 (CXCL4)­specific antibody was purified by affinity chromatography and then biotinylated.

Catalog Number: (10775-028)

Supplier: Peprotech

Description: Produced from sera of rabbits immunized with highly pure Recombinant Human IGF-II. Anti­Human IGF-II­specific antibody was purified by affinity chromatography and then biotinylated.

Catalog Number: (10775-030)

Supplier: Peprotech

Description: Anti-IgG Rabbit Polyclonal Antibody (Biotin) IGF-II

Supplier: Peprotech

Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs, PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules, and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant Human PDGF-AB is a 26.4 kDa disulfide-linked dimer, consisting of one α chain and one β chain (234 total amino acids).

Supplier: Peprotech

Description: Produced from sera of rabbits immunized with highly pure Recombinant Human BD-1. Anti­Human BD-1­specific antibody was purified by affinity chromatography and then biotinylated.

Supplier: Peprotech

Description: Produced from sera of rabbits immunized with highly pure Recombinant Human NNT-1/BCSF-3. Anti­Human NNT-1/BCSF-3­specific antibody was purified by affinity chromatography employing an immobilized Human NNT-1/BCSF-3 matrix.

Supplier: Peprotech

Description: IL-23 is a proinflammatory, heterodimeric protein composed of two subunits: a unique p19 subunit, and a p40 subunit that is shared with IL-12. IL-23 is secreted by activated dendritic cells and macrophages, and signals though a receptor comprised of IL-23R complexed with IL-12Rβ2. IL-23 has been shown to enhance proliferation of memory T cells. It also stimulates the production of IFN-γ in NK cells, induces IL-17 production, and drives Th17-mediated responses. Recombinant Human IL-23 is a 53.5 kDa, heterodimeric protein consisting of the two subunits, p19 (170 amino acids) and p40 (306 amino acids).

Supplier: Peprotech

Description: IL-17B is a disulfide-linked homodimer of two 161 amino acid polypeptide chains. It belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region, but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17B is expressed by T-cells, and has been shown to stimulate release of TNF-α and IL-1β from cells of the monocyte lineage. Recombinant Human IL-17B is a 36.6 kDa non-disulfide-linked homodimer of two 161 amino acid polypeptide chains.

Supplier: Peprotech

Description: IL-22 is a member of the IL-10 family of regulatory cytokines, which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10Rβ/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family. Recombinant Human IL-22 is a 33.6 kDa, non-disulfide-linked, homodimeric protein consisting of two 147 amino acid polypeptide chains.

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Supplier: Peprotech

Description: Thrombomodulin (TM, CD141, THBD) is an endothelial cell-expressed, transmembrane glycoprotein that can form a complex with the coagulation factor, thrombin. The thrombomodulin/thrombin complex converts protein C to its activated form, protein Ca, which in turn proteolytically cleaves and deactivates factor Va and factor VIIIa, two essential components of the coagulation mechanism. This inactivation reduces the generation of additional thrombin, and thereby effectively prevents continued coagulation. Reduced levels of thrombomodulin can correlate with the pathogenesis of certain cardiovascular diseases, such as atherosclerosis and thrombosis. However, the serum levels of the truncated circulating form of thrombomodulin are typically elevated during inflammation and in the presence of various inflammatory-related diseases. The thrombomodulin protein contains 575 amino acids, including an 18 a.a. signal sequence, a 497 a.a. extracellular domain, a 24 a.a. transmembrane sequence, and a 36 a.a. cytoplasmic region. Recombinant Human Thrombomodulin is a 51.4 kDa, 491-amino-acid length glycoprotein containing the extracellular domain of thrombomodulin.

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