You Searched For: Peprotech

Supplier: Peprotech

Description: The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36 α (IL-1F6), β (IL-1F8) and γ (IL-1F9). IL-36γ is highly expressed in psoriatic plaques and in tissues containing epithelial cells. IL-36γ signals through the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells. The interaction of the IL-1Rrp2 receptor with IL-36 ligands induces dendritic cell maturation and activation. IL-36γ also functions as an agonist of NF-κB, and can stimulate the inflammatory response in bronchial epithelial cells. Recombinant Human IL-36γ is a 17.0 kDa protein containing 152 amino acid residues. Manufactured using all Animal-Free reagents.

Catalog Number: (10781-462)

Supplier: Peprotech

Description: Monoclonal AntibodyProduced in mice immunized with highly pure Recombinant Human sIL-2 Receptor α. Anti­Human sIL-2 Receptor α­specific antibody was purified from cell culture by Protein G affinity chromatography.

Supplier: Peprotech

Description: LAG-1 is CC chemokine that signals through the CCR5 receptor. LAG-1 is identical to MIP-1β (ACT II isotype) except for two amino acid substitutions; arginine for histidine at position 22 and serine for glycine at position 47 of the mature protein. LAG-1 chemoattracts monocytes, and exhibits activity as an HIV-suppressive factor. Recombinant Human LAG-1 (CCL4L1) is a 7.7 kDa protein containing 69 amino acid residues.

Supplier: Peprotech

Description: Human soluble DLL-1 comprises the extracellular signaling domain of DLL-1, a member of the Delta/Serrate/Lag-2 (DSL) family of single-pass type I trans-membrane proteins that serve as ligands for Notch receptors. It is expressed primarily in the heart, pancreas and epidermis. DLL-1 functions to specifically activate the Notch-1 and Notch-2 receptors. Proteolytic cleavage of DLL-1 produces a secreted extracellular domain, sDLL-1, that interacts with Notch receptors expressed on adjacent cells. Notch signaling plays an essential role in controlling cell fate decisions during prenatal development and postnatal stem cell renewal, and differentiation in many tissues. Human sDLL-1 blocks monocyte differentiation into macrophages, but permits differentiation into dendritic cells. In hematopoietic progenitor cells, hsDLL-1, suppresses differentiation into B-cells, while promoting differentiation into T-cells and NK cell precursors. In cell culture, human sDLL-1 has been shown to promote expansion of hematopoietic progenitor cells and suppress apoptosis by inhibiting differentiation. Overexpression of Notch receptors appears to inhibit differentiation in several mammalian cell lines, and increasing evidence suggests that Notch signaling is frequently downregulated in human malignancies. The human DLL-1 gene consists of a 528 amino acid extracellular domain with one DSL domain, eight EGF-like repeats, a 23 amino acid transmembrane domain, and a 155 amino acid cytoplasmic domain. The calculated molecular weight of Recombinant Human sDLL-1 is 56.3 kDa.

Supplier: Peprotech

Description: The Insulin/Relaxin structural family of proteins consists of at least seven members, each containing an insulin-like heterodimeric structure of two polypeptide chains held together by two inter-chain disulfide bonds. The INSL5/INSL7 hybrid contains the β-chain of INSL7 (Relaxin-3), linked to the α-chain of INSL5. The INSL5/INSL7 hybrid protein can specifically activate the G protein-coupled receptors, GPCR135 and GPCR142, but unlike Relaxin-3, does not induce significant activation of the LGR7 receptor. Recombinant Human INSL5/INSL7 Hybrid is a heterodimeric, 5.2 kDa protein consisting of a 27 amino acid β-chain linked to a 21 amino acid α-chain by two disulfide bonds.

Supplier: Peprotech

Description: Produced from sera of rabbits immunized with highly pure Recombinant Human FGF-17. Anti­Human FGF-17­specific antibody was purified by affinity chromatography employing an immobilized Human FGF-17 matrix.

Supplier: Peprotech

Description: Produced from sera of rabbits immunized with highly pure Recombinant Human EGF Receptor (EGFR). Anti­Human EGF Receptor (EGFR)­specific antibody was purified by affinity chromatography employing an immobilized Human EGF Receptor (EGFR) matrix.

Supplier: Peprotech

Description: Produced from sera of rabbits immunized with highly pure Recombinant Human NOV. Anti­Human NOV­specific antibody was purified by affinity chromatography and then biotinylated.

Supplier: Peprotech

Description: Produced from sera of rabbits immunized with highly pure Recombinant Human Wnt-1. Anti­Human Wnt-1­specific antibody was purified by affinity chromatography employing an immobilized Human Wnt-1 matrix.

Supplier: Peprotech

Description: Thrombomodulin (TM, CD141, THBD) is an endothelial cell-expressed, transmembrane glycoprotein that can form a complex with the coagulation factor, thrombin. The thrombomodulin/thrombin complex converts protein C to its activated form, protein Ca, which in turn proteolytically cleaves and deactivates factor Va and factor VIIIa, two essential components of the coagulation mechanism. This inactivation reduces the generation of additional thrombin, and thereby effectively prevents continued coagulation. Reduced levels of thrombomodulin can correlate with the pathogenesis of certain cardiovascular diseases, such as atherosclerosis and thrombosis. However, the serum levels of the truncated circulating form of thrombomodulin are typically elevated during inflammation and in the presence of various inflammatory-related diseases. The thrombomodulin protein contains 575 amino acids, including an 18 a.a. signal sequence, a 497 a.a. extracellular domain, a 24 a.a. transmembrane sequence, and a 36 a.a. cytoplasmic region. Recombinant Human Thrombomodulin is a 51.4 kDa, 491-amino-acid length glycoprotein containing the extracellular domain of thrombomodulin.

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Supplier: Peprotech

Description: All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant Murine MIP-2 (CXCL2) is a 7.8 kDa protein consisting of 73 amino acids, including the ‘ELR’ motif common to the CXC chemokine family that binds to CXCR1 or CXCR2.

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Supplier: Peprotech

Description: IL-8 is a proinflammatory CXC chemokine that can signal through the CXCR1 and CXCR2 receptors. It is secreted by monocytes and endothelial cells. IL-8 chemoattracts and activates neutrophils. Recombinant Human IL-8 (CXCL9) (endothelial-derived) is an 8.9 kDa protein containing 77 amino acid residues.

Supplier: Peprotech

Description: IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses.

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Supplier: Peprotech

Description: Produced from sera of rabbits immunized with highly pure Recombinant Human SDF-1α (CXCL12). Anti­Human SDF-1α (CXCL12)­specific antibody was purified by affinity chromatography and then biotinylated.

Supplier: Peprotech

Description: Produced from sera of rabbits immunized with highly pure Recombinant Human β-NGF. Anti­Human β-NGF­specific antibody was purified by affinity chromatography employing an immobilized Human β-NGF matrix.

Supplier: Peprotech

Description: Produced from sera of rabbits immunized with highly pure Recombinant Human β-NGF. Anti­Human β-NGF­specific antibody was purified by affinity chromatography and then biotinylated.