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Human Recombinant MIA (from E. coli)

Supplier: Peprotech

130-01-5UG 130-01-20UG 130-01-100UG 130-01-250UG 130-01-500UG 130-01-1MG

10779-312EA 143.88 USD

10779-312 10779-314 10779-316 10779-318 10779-320 10779-322

Human Recombinant MIA (from E. coli)

Proteins and Peptides

MIA is the first discovered member of a family of secreted cytokines termed the MIA/OTOR family. The four known members of this family, MIA, MIA-2, OTOR and TANGO, each contain a Src homology-3 (SH3)-like domain. MIA is an autocrine growth regulatory protein, secreted from chondrocytes and malignant melanoma cells that promotes melanoma metastasis by binding competitively to fibronectin and laminin in a manner that results in melanoma cell detachment from the extracellular matrix in vivo . Elevated levels of MIA may represent a clinically useful marker for diagnosis of melanoma metastasis, as well as a potential marker for rheumatoid arthritis. Recombinant Human MIA is a 12.2 kDa globular protein containing 108 amino acid residues, including two intramolecular disulfide bonds.

Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.

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