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You Searched For: Proteins and Peptides

Proteins are used in routine laboratory procedures such as binding enzymes or coupling peptides to carrier proteins. These kits, mixture solutions, and collagen matrices fulfill a myriad of essential laboratory functions for developing relationships between proteins and other cellular components. The stimulating proteins offered have various amino acid arrangements and functions to fulfill any sample manipulation for testing purposes in any field.

Proteins are used in routine laboratory procedures such as binding enzymes or coupling peptides to carrier proteins. These kits, mixture solutions, and collagen matrices fulfill a myriad of essential laboratory functions for developing relationships between proteins and other cellular components. The stimulating proteins offered have various amino acid arrangements and functions to fulfill any sample manipulation for testing purposes in any field.


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Product Image-77750-016

Human Recombinant BDNF (from E. coli)

Supplier: VWR International
Description: <p>Brain-derived neurotrophic factor (BDNF) is a nerve growth factor that binds two receptors, the low-affinity nerve growth factor receptor (LNGFR) and the tropomyosin receptor kinase B (TrkB), to support neuron growth and survival.  BDNF expression in the hippocampus is essential for long-term memory storage and learning.  Human, mouse, rat, and pig BDNF are cross-reactive.</p>

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Product Image-77750-032

Human Recombinant GDNF (from E. coli cells)

Supplier: VWR International
Description: Glial cell-derived neurotrophic factor (GDNF) is a neurotrophic factor that signals through a multicomponent receptor system to activate receptor tyrosine kinase RET signaling. GDNF promotes dopamine uptake, prevents motor neuron apoptosis, and supports the survival and differentiation of neurons.

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Product Image-77750-066

Human Recombinant SCF (from E. coli)

Supplier: VWR International
Description: Stem cell factor (SCF) is a cytokine made by fibroblasts and endothelial cells. SCF binds to the receptor c-Kit/CD117 and plays a critical role in the maintenance, survival, and differentiation of hematopoietic stem cells. While human SCF shows no activity on murine cells, murine and rat SCF are active on human cells.

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Product Image-77750-234

Human Recombinant IL-7 (from E. coli)

Supplier: VWR International
Description: Interleukin 7 (IL-7) is a hematopoietic cytokine that is an important regulator of B and T cell development. IL-7 is secreted by bone marrow and thymic stromal cells, dendritic cells, intestinal epithelial cells, hepatocytes, and keratinocytes. IL-7 signals through the interleukin 7 receptor (IL-7R) to promote the differentiation of hematopoietic stem cells into T cells, B cells, and natural killer cells. IL-7 is also a regulator of intestinal mucosal lymphocyte proliferation. Human and mouse IL-7 show species cross-reactivity.

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Product Image-77750-316

Human Recombinant MCP-4 (from E. coli)

Supplier: VWR International
Description: Monocyte chemotactic protein 4 (MCP-4), also called CCL13, is induced by inflammatory proteins such as interleukin 1 (IL-1) and tumor necrosis factor alpha (TNF-α). MCP-4 is a ligand for the G protein coupled chemokine receptors CCR2, CCR3, and CCR5. MCP-4 activates signaling in monocytes, T lymphocytes, eosinophils, and basophils during inflammation and allergic responses.

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Product Image-77750-780

Human Recombinant PDGF-AB (from E. coli)

Supplier: VWR International
Description: Platelet-derived growth factor (PDGF) is an important regulator of cell growth, proliferation, and angiogenesis. PDGF synthesis is induced by IL-1, IL-6, TNF-α, TGF-β and EGF signaling. PDGF functions as a mitogenic growth hormone on cells of mesenchymal lineage, such as smooth muscle and glial cells. PDGF is also stored in the alpha-granules of platelets and is released upon adherence to traumatized tissues.

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Product Image-77750-470

Human Recombinant IL-17E (from E. coli)

Supplier: VWR International
Description: Interleukin 17E (IL-17E), also known as IL-25, is a member of the IL-17 family of cytokines. IL-17E binds to the IL-17RB receptor to stimulate the secretion of the proinflammatory interleukin 8 (IL-8) chemokine and to induce the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB).

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Product Image-77750-574

Human Recombinant RELM-B (from E. coli)

Supplier: VWR International
Description: Resistin-like molecule-beta (RELM-β) is a member of the RELM family of secreted proteins containing conserved C-terminus cysteines. The RELM family consists of Resistin (FIZZ3), RELM-α (FIZZ1), RELM-β (FIZZ2), and RELM-ɣ (FIZZ4). Resistin and RELM-β are the only RELM family members found in humans, whereas all four RELM family members are present in rodents. RELM-β functions to increase fibroblast proliferation and differentiation, resulting in airway remodeling and increased inflammation.

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Product Image-77751-878

Mouse Recombinant IL-3 (from E. coli)

Supplier: VWR International
Description: Interleukin 3 (IL-3) is a cytokine that is produced by activated T cells and mast cells.  IL-3 induces the differentiation of hematopoietic stem cells into myeloid precursor cells, such as erythrocyte, megakaryocyte, granulocyte, monocyte, and dendritic cells.  IL-3 also functions in the nervous system and is important during the B-1 cell regulation of chronic inflammatory diseases.  

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Product Image-77750-968

Human Recombinant PLGF-3 (from E. coli)

Supplier: VWR International
Description: Placenta growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family and promotes endothelial cell growth and angiogenesis. PlGF is secreted as a homodimer and may also form a heterodimer with VEGF. PlGF is detected in the placenta, heart, lungs, thyroid, and adipose tissues. Circulating PlGF levels are correlated with colorectal and renal cancers, as well as atherosclerosis and ischemic heart disease. There are four alternatively spliced PlGF isoforms (PlGF-1, PlGF-2, PlGF-3, and PlGF-4), each with unique secretion patterns and heparin-binding affinities. PlGF-3 lacks a heparin-binding domain and signals through the VEGFR-1 receptor.

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Product Image-77751-342

Human Recombinant FGF-4 (from E. coli)

Supplier: VWR International
Description: Fibroblast growth factor 4 (FGF-4) is a secreted growth factor that is predominantly expressed during bone morphogenesis and embryonic limb development.  FGF-4 is an important growth regulator for stem cells, fibroblasts, and endothelial cells.  FGF-4 contains a single N-linked glycosylation signal.  In-vitro studies suggest that unglycosylated FGF-4 is cleaved into 13 kDa and 15 kDa truncated proteins that have greater biological activity than the wild type 19 kDa FGF-4 protein.  Human FGF-4 shares high homology and is cross-reactive with mouse FGF-4. 

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Product Image-77752-236

Mouse Recombinant TNF-A (from E. coli)

Supplier: VWR International
Description: <p>Tumor necrosis factor alpha (TNF-α) is an inflammatory cytokine secreted by macrophages, monocytes, neutrophils, T cells, and NK-cells following stimulation by bacterial lipopolysaccharide (LPS).  TNF-α signal activation occurs through two receptors, TNFR1 and TNFR2. TNFR1 is expressed on most cell types, unlike TNFR2, which is expressed mainly on immune cells. TNF-α functions to stimulate phagocytosis in macrophages, chemoattract neutrophils, increase insulin resistance, and induce fever.</p>

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Product Image-77750-856

Human Recombinant FGF-7/KGF (from E. coli)

Supplier: VWR International
Description: <p>Fibroblast growth factor 7 (FGF-7), also known as keratinocyte growth factor (KGF), is a potent mitogen that regulates epithelial cell migration and differentiation. FGF-7 is produced by mesenchymal cells and binds in high affinity to a splice variant of FGF receptor 2 (FGFR2-IIIb). The mitogenic activity of FGF-7 acts predominantly on keratinocytes, but not on fibroblast or endothelial cells. FGF-7 expression is upregulated after acute and chronic injury, suggesting that FGF-7 functions during the healing of injured epithelial cells. FGF-7 also induces the formation of the apical ectodermal ridge during limb development.</p>

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Product Image-77750-994

Human Recombinant FGF-5 (from E. coli)

Supplier: VWR International
Description: Fibroblast growth factor 5 (FGF-5) is a secreted heparin-binding growth factor that binds to FGF receptors 1 and 2 (FGFR1 and FGFR2). FGF-5 is expressed in the mesenchyme, skeletal muscles, central nervous system, and hair follicles to promote cell differentiation and proliferation. FGF-5 functions as a regulatory factor during hair elongation and skeletal muscle development.

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Product Image-77751-178

Human Recombinant IL-2C126S (from E. coli cells)

Supplier: VWR International
Description: IL-2C126S, an immune-regulating cytokine originating from lymphocytes, operates via the IL-2R receptor to trigger the expansion of activated T cells and encourage T cell maturation (1). IL-2 mediates its action by binding to IL-2 receptors (IL-2R), consisting of either trimeric receptors made of IL-2Rα (CD25), IL-2Rβ (CD122), and IL-2Rγ (γc, CD132) chains or dimeric βγ IL-2Rs (2).

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Human Recombinant TGF-A (from E. coli)

Supplier: VWR International
Description: Tumor growth factor alpha (TGF-α) is a member of the epidermal growth factor (EGF) family. TGF-α function is mediated through binding the EGF receptor (EGFR) to activate receptor tyrosine kinase signaling. TGF-α functions as a mitogen to activate epithelial cell proliferation, growth, and differentiation. In the gastric mucosa, TGF-α production inhibits gastric acid secretion and therefore plays a central role in the pathogenesis of the stomach syndrome Ménétrier's disease. TGF-α is also produced in adult macrophages, brain cells, keratinocytes, and is widely expressed in cancer cells.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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