You Searched For: STEMCELL Technologies

Catalog Number: (MSPP-02698)

Supplier: STEMCELL Technologies

Description: Low-density lipoproteins pre-screened for hematopoietic cell growth.

Catalog Number: (MSPP-100-1451)

Supplier: STEMCELL Technologies

Description: Ideal for the permeabilization of fixed cells during labeling of cytokines and other cytoplasmic antigens.

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Catalog Number: (MSPP-7200)

Supplier: STEMCELL Technologies

Description: HEPES Buffer Solution is a biological buffer used in cell culture media.

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Supplier: STEMCELL Technologies

Description: Thrombopoietin (TPO) is a key regulator of megakaryocytopoiesis and thrombopoiesis <i>in vitro</i> and <i>in vivo</i>. TPO stimulates the proliferation and maturation of megakaryocytes and has an important role in regulating the level of circulating platelets <i>in vivo</i>. TPO also promotes the survival, self-renewal, and expansion of hematopoietic stem cells and primitive multilineage progenitor cells. It is commonly used with other cytokines such as stem cell factor (SCF) and Flt3/Flk-2 Ligand to promote expansion of primitive hematopoietic cells in culture (Hitchcock andamp; Kaushansky). The TPO receptor, c-Mpl, is expressed at all stages of megakaryopoiesis, from hematopoietic stem and progenitor cells to mature platelets.

Supplier: STEMCELL Technologies

Description: Animal component-free non-specific protease.

Supplier: STEMCELL Technologies

Description: Defined, serum-free medium for neural induction of human ES and iPS cells.

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Supplier: STEMCELL Technologies

Description: B cell activating factor (BAFF) is part of the tumor necrosis factor (TNF) superfamily and is expressed by monocytes, macrophages, dendritic cells, and neutrophils (Mackay and amp; Browning; Scapini <i>et al.</i>). It binds to three receptors: BAFF-R, TACI, and BCMA, all of which are expressed by B cells at various times in their development (Liu and amp; Davidson). BAFF-R signaling activates the NF-kB signaling pathway, and promotes B cell survival, Ig class switching, and antigen presentation (Bossen and amp; Schneider; Liu and amp; Davidson; Naradikian <i>et al.</i>). BAFF also has functions in other cell types: it promotes monocyte survival and activation, proinflammatory cytokine secretion, and differentiation into macrophages (Chang <i>et al.</i>), and co-stimulates anti-CD3-mediated activation of human T cells (Huard <i>et al.</i>; Mackay and amp; Leung).

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Catalog Number: (MSPP-100-0920)

Supplier: STEMCELL Technologies

Description: For detection of caspase-3/7 activity in cell lysates prepared from mammalian cells undergoing apoptosis - 200 tests.

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Catalog Number: (MSPP-781611006)

Supplier: STEMCELL Technologies

Description: Fibroblast growth factor (FGF) 9 is a pleiotropic member of the FGF family. FGFs are heparin-dependent regulators of cell proliferation and differentiation (Itoh and Ornitz). FGF-9 signals by binding FGFR3 (IIIb) and the IIIc splice variants of the FGFR1, FGFR2, and FGFR3 receptors (Santos-Ocampo <i>et al.</i>; Mohammadi <i>et al.</i>; Plotnikov <i>et al.</i>). In mice, deletion of FGF-9 is lethal and expression of FGF-9 affects development of the skeleton, cerebellum, lungs, heart, vascular system, digestive tract, and testes (Colvin <i>et al.</i>; Harada <i>et al.</i>; Lin <i>et al.</i>). Altered levels of FGF-9 have also been reported in various types of human cancers (Leushacke <i>et al.</i>; Abdel-Rahman <i>et al.</i>).

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Catalog Number: (MSPP-100-0872)

Supplier: STEMCELL Technologies

Description: Differentiation and maturation kits for generation of motor neurons from human pluripotent stem cells.

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Catalog Number: (MSPP-100-1296)

Supplier: STEMCELL Technologies

Description: A member of the SIBLING family of glycoproteins (Rangaswami <i>et al.</i>), Osteopontin (OPN) functions as T-helper 1 cytokine, and plays an important role in cell signaling, migration, and activation (Weber <i>et al.</i>, 2002). Osteopontin has been shown to regulate inflammation both <i>in vitro</i> and <i>in vivo</i> (Agnholt <i>et al.</i>; Kiefer <i>et al.</i>), and has been implicated in the pathophysiology of numerous cancers, including prostate (Thalmann <i>et al.</i>), lung (Chambers <i>et al.</i>), ovarian (Kim <i>et al.</i>), and breast etiologies (Weber <i>et al.</i>, 2015). In humans, OPN is initially secreted as a 317 amino acid protein which is subject to tissue-specific post-translational modifications by glycosylation, phosphorylation, and transglutamination (Kazanecki <i>et al.</i>; Sodek <i>et al.</i>). This protein product contains a His-residue tag at the amino end of the polypeptide chain. For consistency and reproducibility across your applications, Osteopontin from STEMCELL comes lyophilized with ≥ 92% purity, and endotoxin levels are verified to be ≤1.0 EU/μg protein.

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Catalog Number: (MSPP-100-0130)

Supplier: STEMCELL Technologies

Description: For culture and expansion of human hematopoietic cells - 500 ml.

Supplier: STEMCELL Technologies

Description: Stem cell factor (SCF) is an early-acting cytokine that plays a pivotal role in the regulation of embryonic and adult hematopoiesis. SCF promotes cell survival, proliferation, differentiation, adhesion, and functional activation of cells at multiple levels of the hematopoietic hierarchy. Together with other cytokines such as thrombopoietin and Flt3/Flk-2 Ligand, SCF is commonly used to promote expansion of primitive hematopoietic stem cells and multi-potent progenitor cells in culture (Martin <i>et al.</i>; Kent <i>et al.</i>). In synergy with various growth factors, including IL-2, IL-3, IL-6, IL-7, G-CSF, and erythropoietin, SCF increases proliferation and differentiation of myeloid and erythroid progenitor cells and a subset of lymphoid progenitor cells (Broudy). SCF is also a primary growth and activation factor for mast cells and eosinophils. SCF exists in two biologically active splice forms: a soluble and a transmembrane isoform. Upon binding to its receptor (c-Kit tyrosine kinase receptor; CD117), it activates PI3K, JAK/STAT, and MAPK pathways. SCF and signaling from c-Kit have also been reported to play an important role in pigmentation, fertility, vasculogenesis, motility of the gut via c-Kit positive interstitial cells of Cajal, and in the migration of neuronal stem and progenitor cells to sites of injury in the brain. This product is animal component-free.

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Catalog Number: (MSPP-100-1390)

Supplier: STEMCELL Technologies

Description: Stimulating T cells with EBV (GP350/340) Peptide Pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. EBV (GP350/340) Peptide Pool is a lyophilized mixture of 224 peptides from envelope glycoprotein GP350 (GP350/340) of Epstein-Barr virus (EBV; strain B95-8), and consists of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 - 907 on GP350/340. GP350 meditates EBV attachment to B lymphocytes via binding to the cell surface receptor CR2 (also known as C3d receptor or CD21) (Nemerow <i>et al.</i>; Tanner <i>et al.</i>). Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.

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Catalog Number: (MSPP-03803)

Supplier: STEMCELL Technologies

Description: Hybridoma fusion recovery medium (serum-containing).

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Catalog Number: (MSPP-04447)

Supplier: STEMCELL Technologies

Description: Pre-aliquoted methylcellulose-based medium with recombinant cytokines for rapid hematopoietic colony assays of human cells. 24×3 ml vials.

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