You Searched For: SOUTHERN BIOTECHNOLOGY MS

Catalog Number: (103265-538)

Supplier: Southern Biotechnology

Description: Glial fibrillary acid protein (GFAP) is a member of the type III intermediate filament family of proteins. GFAP is heavily expressed in astrocytes and certain other astroglia in the central nervous system, in satellite cells in peripheral ganglia, and in non-myelinating Schwann cells in peripheral nerves. It is closely related to its non-epithelial family members, vimentin, desmin, and peripherin, which are all involved in the structure and functions of the cell’s cytoskeleton. GFAP is thought to help to maintain astrocyte mechanical strength, as well as the shape of cell; however, its precise function remains poorly understood. In adults, GFAP levels increase in response to the proliferation of astrocytes associated with Alzheimer’s disease, epilepsy, and multiple sclerosis. Antibodies specific for GFAP are useful as markers of astrocytic cells and neural stem cells as well as for distinguishing neoplasms of astrocytic origin from other neoplasms in the central nervous system.

Catalog Number: (103265-550)

Supplier: Southern Biotechnology

Description: Fas ligand (CD178) is a 40 kD type II transmembrane protein that is a member of the tumor necrosis factor superfamily. This well characterized potent apoptotic factor is utilized by cytotoxic T cells and natural killer cells to selectively kill virus infected and tumorigenic cells. Moreover, studies indicate that Fas ligand is an important regulator in immune homeostasis where it has been shown to down-regulate immune responses during activation-induced cell death. Fas ligand initiates apoptosis by binding to its receptor, CD95, on target cells which facilitates recruitment of numerous signaling proteins to form a death inducing signaling complex. This signaling complex is then believed to propagate the apoptotic signal through the recruitment and activation of caspase-8. The SB93a monoclonal antibody detects a band at ~40 kDa corresponding to the transmembrane/insoluble form of Fas ligand.

Catalog Number: (103265-592)

Supplier: Southern Biotechnology

Description: Purified Goat Anti-Mouse IgG1 antibody for use in ELISA and immunocytochemistry assays.

Catalog Number: (103264-660)

Supplier: Southern Biotechnology

Description: The monoclonal antibody 27-11-13S recognizes with the α3 domain of H-2Db class I MHC antigen. The antibody cross-reacts with the α3 domain of H-2Dd, H-2Dq, H-2Ld and H-2Lq but not H-2Kb. Reactivity with haplotypes k, f, p, r, and s has not been observed.

Catalog Number: (103264-608)

Supplier: Southern Biotechnology

Description: Ly-6A/E, also known as Sca-1, is a member of the Ly-6 multigene family of type V glycophosphatidylinositol-anchored cell surface proteins. It is expressed on multipotent hematopoietic stem cells in bone marrow of mice with both the Ly-6.1 and Ly-6.2 allotypes. In the periphery, Ly-6A/E exhibits a pattern of expression which is based on differences between the two allotypes. Ly-6.1 strains (e.g., A, BALB/c, CBA, C3H/He, DBA/1, NZB) have few Ly-6A/E+ resting peripheral lymphocytes whereas Ly-6.2 strains (e.g., AKR, C57BL, C57BR, C57L, DBA/2, PL, SJL, SWR, 129) have relatively high numbers of Ly-6A/E+ lymphocytes. The expression of Ly-6A/E is dramatically upregulated in all strains upon cellular activation. Studies with the monoclonal antibody D7 suggest that Ly-6A/E may be involved in B and T lymphocyte responses and it appears that the antigen may be required for T-cell receptor-mediated T-cell activation.

Catalog Number: (103264-632)

Supplier: Southern Biotechnology

Description: The CD45 antigen is an essential regulator of leukocyte activation and development and is now known to be a protein tyrosine phosphatase, e.g., CD45 is able to dephosphorylate the Src family of protein kinases. This activity is now known to be required for signal transduction induced by T and B cell antigen receptor engagement, cytokine signaling, and Fc receptor stimulation. The functional state of CD45 also has a pronounced effect on lymphocyte development. CD45 exists in multiple forms, such as the restricted variants (CD45R; see companion products 1660, 1665, 1675, 1685, and 1820) and as allelic forms CD45.1 (Ly-5.1) and CD45.2 (Ly-5.2). The former arises as a result of alternative splicing of different exons. The specificity of antibodies to CD45.1 and CD45.2 has been exploited in studies where resolution of donor and recipient cells is essential, such as in gene therapy or bone marrow transplantation. The monoclonal antibody A20 recognizes all mouse leukocytes expressing the CD45.1 allotype.

Catalog Number: (103264-610)

Supplier: Southern Biotechnology

Description: Ly-6A/E, also known as Sca-1, is a member of the Ly-6 multigene family of type V glycophosphatidylinositol-anchored cell surface proteins. It is expressed on multipotent hematopoietic stem cells in bone marrow of mice with both the Ly-6.1 and Ly-6.2 allotypes. In the periphery, Ly-6A/E exhibits a pattern of expression which is based on differences between the two allotypes. Ly-6.1 strains (e.g., A, BALB/c, CBA, C3H/He, DBA/1, NZB) have few Ly-6A/E+ resting peripheral lymphocytes whereas Ly-6.2 strains (e.g., AKR, C57BL, C57BR, C57L, DBA/2, PL, SJL, SWR, 129) have relatively high numbers of Ly-6A/E+ lymphocytes. The expression of Ly-6A/E is dramatically upregulated in all strains upon cellular activation. Studies with the monoclonal antibody D7 suggest that Ly-6A/E may be involved in B and T lymphocyte responses and it appears that the antigen may be required for T-cell receptor-mediated T-cell activation.

Catalog Number: (103264-652)

Supplier: Southern Biotechnology

Description: Ly-6G/Ly-6C, formerly known as the myeloid differentiation antigen Gr-1, is a GPI-anchored protein. In the bone marrow, the level of antigen expression is directly correlated with granulocyte differentiation and maturation. It is also transiently expressed on monocytes in the bone marrow. In the periphery, Ly-6G/Ly-6C is expressed predominantly on neutrophils.

Catalog Number: (103264-800)

Supplier: Southern Biotechnology

Description: Purified Goat Anti-Human IgG(H+L) antibody with minimal reactivity to rabbit, mouse, rat, bovine, horse, hamster, goat, sheep, chicken, and guinea pig serum proteins for use in ELISA assays.

Catalog Number: (103264-352)

Supplier: Southern Biotechnology

Description: Goat Anti-Mouse IgM-Alexa Fluor 647 antibody with minimal reactivity to human proteins for use in flow cytometry, immunohistochemistry / immunocytochemistry, and western blotting assays.

Catalog Number: (103264-356)

Supplier: Southern Biotechnology

Description: Goat Anti-Mouse IgM-Alexa Fluor 488 antibody for use in flow cytometry, immunohistochemistry / immunocytochemistry, and western blotting assays.

Catalog Number: (103264-392)

Supplier: Southern Biotechnology

Description: Goat Anti-Mouse IgG Fc-AP antibody for use in ELISA and western blotting assays.

Catalog Number: (103264-376)

Supplier: Southern Biotechnology

Description: Goat Anti-Mouse IgG-Alexa Fluor 647 antibody with minimal reactivity to human proteins for use in flow cytometry, immunohistochemistry / immunocytochemistry, and western blotting assays.

Catalog Number: (103265-084)

Supplier: Southern Biotechnology

Description: Donkey Anti-Rat IgG(H+L)-Alexa Fluor 488 antibody with minimal reactivity to mouse serum proteins for use in immunohistochemistry / immunocytochemistry and western blotting assays.

Catalog Number: (103265-048)

Supplier: Southern Biotechnology

Description: Donkey F(ab')2 Anti-Mouse IgG(H+L)-Biotin antibody for use in ELISA assays.

Catalog Number: (103265-204)

Supplier: Southern Biotechnology

Description: Alexa Fluor 488 Anti-Human IgA1 antibody for use in flow cytometry, immunohistochemistry / immunocytochemistry, and western blotting assays.