Anti-TBR1 (IDDAS) Rabbit Polyclonal Antibody [clone: Poly]

Supplier: STEMCELL Technologies
100-1341
MSPP-100-1341EA 1094.69 USD
MSPP-100-1341
Anti-TBR1 (IDDAS) Rabbit Polyclonal Antibody [clone: Poly]
Antibodies
Rabbit polyclonal antibody against human, mouse, rat TBR1 (IDDAS).

  • Neural cells Psc derived
  • Neurons

This rabbit polyclonal antibody reacts with human, mouse and rat T-box brain 1 (TBR1), a transcription factor highly expressed and involved in human development; mutations of the T-box gene have been linked to developmental disorders as well as the manifestation of certain cancers. Use this polyclonal antibody in applications requiring detection of TBR1, such as ELISA, western blot (WB), immunohistochemistry (IHC), immunocytochemistry (ICC), and immunofluorescence (IF). This antibody clone has been verified for labeling TBR1-positive cortical neurons in hPSC-derived cerebral organoids generated with STEMdiff™ Cerebral Organoid Kit (Catalog #08570) and STEMdiff™ Cerebral Organoid Maturation Kit (Catalog #08571). The T-box transcription factor family consists of five subfamilies, with the TBR1 family of proteins responsible for brain development, primarily through the function of T-box proteins that act as transcriptional activators and inhibitors. In particular, the function of TBR1 in brain development is primarily facilitated by the differentiation of neural stem cells (NSCs) in both developing and adult brains. Structurally, T-box transcription factors contain a conserved DNA-binding motif named T-box domain, spanning 180-200 amino acid residues to bind DNA. Studies involving TBR1-deficient mice found defects in the frontal cortex and layer 6 differentiation.

Caution: Product restrictions: (i) Customer shall not make products or any portion of them in any way, shape or form, including as a component of another product available for the purpose of further resale or alter or remove the Product label and the Supplier’s mark of origin without express written permission of Supplier and (ii) Customer is familiar with Supplier’s restrictions on the use of the products and shall use the products in compliance with such restrictions and the applicable Supplier Product Information sheet (collectively, the 'Product Restrictions').

Type:
Antigen: TBR1 (IDDAS)
Clonality: Polyclonal
Clone: Poly
Conjugation:
Epitope:
Host: Rabbit
Isotype:
Reactivity: Human, Mouse, Rat
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