Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD2, FITC-conjugated.
The RPA-2.10 antibody reacts with CD2, an ~50 kDa type I transmembrane glycoprotein and a member of the immunoglobulin (Ig) superfamily; two Ig-like domains are located in its extracellular portion. CD2 is broadly expressed on peripheral T and NK cells, dendritic cells, erythrocytes, most thymic T cells, subsets of thymic B cells, and on the endothelium. CD2 expression appears early during T cell differentiation. Aberrant expression has been observed in some lymphomas and myeloid leukemias. CD2 is critically important for T cell activation and signaling, as well as lymphocyte adhesion. The primary ligand for CD2 is CD58 (LFA-3) located on antigen-presenting cells, with additional ligands comprising CD15 (SSEA-1), CD48 and CD59. Notably, the RPA-2.10 antibody blocks the mixed lymphocyte reaction.
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Type:
Antigen: CD2
Clonality: Monoclonal
Clone: RPA-2.10
Conjugation: FITC
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Baboon;Capuchin monkey;Chimpanzee;Cynomolgus monkey;Human;Pig;Pigtailed macaque;Rhesus monkey;Squirrel monkey