Anti-CD11b Rat Monoclonal Antibody [clone: M1/70]

Supplier: STEMCELL Technologies
100-0433
MSPP-100-0433EA 197.31 USD
MSPP-100-0433
Anti-CD11b Rat Monoclonal Antibody [clone: M1/70]
Antibodies
Rat monoclonal IgG2b antibody against human, mouse, rhesus CD11b.

  • Granulocytes
  • Subsets
  • Monocytes

The M1/70 antibody reacts with CD11b, an ~170 kDa type 1 transmembrane glycoprotein which associates non-covalently with CD18 to form the heterodimeric Mac-1 receptor. Through its interactions with ligands such as ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, and fibrinogen, Mac-1 functions in several processes, including the adherence of neutrophils and monocytes to stimulated endothelium and phagocytosis of complement-coated particles. CD11b is expressed on the surface of granulocytes, monocytes, NK cells, dendritic cells, tissue macrophages, and subsets of T and B cells, and has been used as a marker to distinguish naïve and memory CD8+ T cells. CD11b is a relatively late marker for myeloid differentiation and is undetectable on most myelomonocytic hematopoietic progenitor cells and more primitive cells. The M1/70 antibody reportedly blocks iC3b binding to Mac-1. This antibody clone has been verified for purity assessments of cells isolated with EasySep™ kits, including EasySep™ Mouse Monocyte Isolation Kit (Catalog #19861).

Caution: Product restrictions: (i) Customer shall not make products or any portion of them in any way, shape or form, including as a component of another product available for the purpose of further resale or alter or remove the Product label and the Supplier’s mark of origin without express written permission of Supplier and (ii) Customer is familiar with Supplier’s restrictions on the use of the products and shall use the products in compliance with such restrictions and the applicable Supplier Product Information sheet (collectively, the 'Product Restrictions').

Type:
Antigen: CD11b
Clonality: Monoclonal
Clone: M1/70
Conjugation: Unconjugated
Epitope:
Host: Rat
Isotype: IgG2b kappa
Reactivity: Baboon, Chimpanzee, Human, Rabbit, Rhesus monkey
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