Rat monoclonal antibody against mouse IL-4, unconjugated.
This monoclonal antibody reacts with mouse interleukin-4 (IL-4), a 14 kDa cytokine that is expressed by Th2-biased CD4+ T cells, mast cells, basophils, and eosinophils. IL-4 is a lymphoid cell growth factor and signals through the IL-4 receptor alpha chain (IL-4Rα) upon binding. This causes the stimulation of activated B and T lymphocytes as well as the differentiation of B cells into plasma cells. Use this recombinant monoclonal antibody in applications requiring detection of IL-4, such as flow cytometry (FC), and the unconjugated antibody in immunocytochemistry (ICC), immunohistochemistry - frozen sections (IHC-F), and FC. IL-4 has the capability to attach and transmit signals through three different cell surface receptors: CD124, CD124 in combination with the common gamma chain (type I complex), or CD124 combined with CD213a1 (type II complex). Signal transducer and activator of transcription 6 (STAT6) has been shown to play an important role in mediating the immune regulatory signal of IL-4. IL-4 has been shown to play a role in normal wound healing and the development of allergic inflammation and asthma.
Caution: Product restrictions: (i) Customer shall not make products or any portion of them in any way, shape or form, including as a component of another product available for the purpose of further resale or alter or remove the Product label and the Supplier’s mark of origin without express written permission of Supplier and (ii) Customer is familiar with Supplier’s restrictions on the use of the products and shall use the products in compliance with such restrictions and the applicable Supplier Product Information sheet (collectively, the 'Product Restrictions').
Type:
Antigen: IL-4
Clonality: Monoclonal
Clone: 11B11
Conjugation: Unconjugated
Epitope:
Host: Rat
Isotype: IgG1 kappa
Reactivity: Mouse