Human Recombinant GAB1 (from Baculovirus (Sf9 Insect Cells))

Supplier: Rockland Immunochemicals

009-001-G66S 009-001-G66

10801-514EA 714 USD

10801-514 10801-512

Human Recombinant GAB1 (from Baculovirus (Sf9 Insect Cells))

Proteins and Peptides

GAB1 is a member of the IRS1-like multisubstrate docking protein family and is a direct substrate of the epidermal growth factor receptor and the insulin receptor (1). GAB1 is tyrosine phosphorylated upon stimulation of cells with various cytokines, growth factors, and antigen receptor. Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains such as SHP2 and phosphatidylinositol 3-kinase. GAB1 is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis (2). GAB1 Protein is ideal for investigators involved in Signaling Proteins, Adaptor Proteins, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Invasion/Metastasis, JAK/STAT Pathway, and Neurobiology research.

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