390 MMP FRET Substrate I, Mca-DNP

Supplier: AnaSpec

AS-27077 AS-27076

102996-760EA 185.62 USD

102996-760 102996-762

390 MMP FRET Substrate I, Mca-DNP

Proteins and Peptides

Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.
This peptide is a fluorogenic substrate that is best cleaved by MMP-7, 8, 9 and 13. The highly fluorescent Mca moiety is efficiently quenched by energy transfer to the Dnp group. The punctuated metallo proteinase (PUMP, EC 3.4.24.23) cleaves the substrate at the Gly-Leu bond with a 190-fold increase in fluorescence (Abs/Em = 325/393 nm). In human MMP assays, this substrate is about 50 to 100 times more sensitive than the generic MMP substrate, Dnp-PLGLWAr-NH2.
Sequence:Mca-PLGL-Dap(Dnp)-AR-NH2
MW:1093.2 Da
% peak area by HPLC:95
Storage condition:-20° C

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