Posaconazole 99%

Supplier: SELLECK CHEMICALS LLC MS

S1257-5MG S1257-25MG
101761-950EA 181.54 USD
101761-950 101761-952 101761-954
Posaconazole 99%
Posaconazole

Posaconazole is an inhibitor primarily of CYP3A4, but it does not inhibit the activity of other CYP enzymes; Also an inhibitor of sterol C14ɑ demethylase inhibitor with IC50 of 0.25 μM.


  • Median terminal elimination half-life of 15 to 35 hours
  • Targets lanosterol 14α-demethylase


Posaconazole also affects and disrupts Ca2+ homeostasis in T.cruzi. Posaconazole blocks the biosynthesis of ergosterol, which is essential for parasite survival. Posaconazole is active against isolates of Candida and Aspergillus spp. that exhibit resistance to Fluconazole, Voriconazole, and Amphotericin B and is much more active than the other triazoles against zygomycetes.

Formula: C₃₇H₄₂F₂N₈O₄
MDL Number: MFCD00941162
CAS Number: 171228-49-2

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