Ursodeoxycholic acid

Supplier: ADIPOGEN CORP MS

Synonyms: 3α,7β-Dihydroxy-5β-cholan-24-oic acid 3α,7β-Dihydroxy-5β-cholanic acid 3α,7β-Dihydroxycholan-24-oic acid 3α,7β-Dihydroxycholanic acid UDCA 7β-Hydroxylithocholic acid 7beta-Hydroxylithocholic acid Ursodiol

AG-CN2-0411-G005 AG-CN2-0411-G001
102988-174EA 166.15 USD
102988-174 102988-172
Ursodeoxycholic acid
Ursodeoxycholic acid

Endogenous hydrophilic bile acid. Antioxidant. Cytoprotective against oxidative stress and cell death. Hepatoprotective at cellular and molecular level, including stabilization of membranes. Protects hepatocytes against bile acid-induced apoptosis. Antiapoptotic and antinecrotic. Targets the mitochondrial function and integrity, reduction of endoplasmatic stress and interactions with survival signals in cAMP, Akt, NF-kappaB, MAPK and PI3K signaling pathways. Modulator and finetuner of the p53-Mdm-2 complex. Chemopreventive against colorectal cancer by countering the tumor-promoting effects of secondary bile acids. Shows also effects on epidermal growth factor receptor (EGFR) signaling and COX-2 expression. Immunomodulator and anti-inflammatory compound. Modifies TLR4 and TLR9 signaling pathways and downregulates the production of proinflammatory tumor necrosis factor-alpha (TNF-alpha). Pregnane X receptor agonist. Neuroprotective. Inhibits neuronal apoptosis. Glucocorticoid Receptor (GR) agonist. Anticholestatic agent. Used to reduce cholesterol absorption and for cholesterol gallstone dissolution. Used to treat primary biliary cirrhosis (PBC). Interferes with the progression of non-alcoholic fatty liver disease (NAFLD)/NASH. Reduces CXCR3 expression. TIMP-1 inducer. ADAM17 inhibitor.

Formula: C₂₄H₄₀O₄
MW: 392.58 g/mol
MDL Number: MFCD00003680
CAS Number: 128-13-2

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