Anti-Proteasome 20S beta5t subunit Mouse Monoclonal Antibody [clone: b8-17]

Supplier: Enzo Life Sciences
PW1020-0025
10050-208EA 161 USD
10050-208
Anti-Proteasome 20S beta5t subunit Mouse Monoclonal Antibody [clone: b8-17]
Antibodies
When cells are stimulated with pro-inflammatory cytokines, most of their constitutively expressed proteasomes are replaced with immunoproteasomes, which increase the production of peptides for presentation on MHC class I molecules. In addition, cortical thymic epithelial cells selectively express a type of proteasome known as the thymoproteasome, in which the β5i immunoproteasome subunit has been replaced by the thymus specific proteasome subunit β5t. The thymoproteasome is required for the positive selection of thymocytes and shaping the T cell receptor repertoire of cytotoxic T lymphocytes. In addition mice deficient in β5t display defective development of CD8(+) T cells in the thymus suggesting a key role for β5t and the thymoproteasome in generating MHC class I-restricted CD8(+) T cells.

Type: Primary
Antigen: Proteasome 20S beta5t subunit
Clonality: Monoclonal
Clone: b8-17
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human, Mouse
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