Anti-SHC1 Mouse Monoclonal Antibody [clone: 11F6]

Supplier: Enzo Life Sciences
905-665-100
10051-924EA 537 USD
10051-924
Anti-SHC1 Mouse Monoclonal Antibody [clone: 11F6]
Antibodies
The Src homology 2 domain containing (Shc) adaptor protein links growth factor, cytokine, and antigen receptor stimulation to the Ras signaling pathway, and plays a critical role in insulin signaling, tumorigenesis, and hematopoietic cell growth and differentiation. Structurally, Shc is composed of an N-terminal phosphotyrosine binding (PTB) domain, a medial CH1 domain, and a C-terminal SH2 domain. Upon binding to activate cell-surface receptors, Shc is phosphorylated at three tyrosine residues (Tyr239, Tyr240, Tyr317) triggering recognition of Shc by SH2-containing proteins such as Grb2.

Type: Primary
Antigen: SHC1
Clonality: Monoclonal
Clone: 11F6
Conjugation: Unconjugated
Epitope: C-Terminal
Host: Mouse
Isotype: IgG1
Reactivity: Human, Mouse
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