Rapamycin (from Streptomyces hygroscopicus) ≥98%
Supplier: ADIPOGEN CORP MS
Synonyms:
(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
Rapamycin, isolated from Streptomyces hygroscopicus, forms a complex with FKBP12 and inhibits the molecular target of rapamycin (mTOR). It blocks the activation of T and B cells.
- Blocks activation of T and B cells
- Antibiotic. Antibacterial and antifungal properties
- Potent immunosuppressant used as an alternative to calcineurin inhibitors
- Cell cycle progression (at the G1/S transition) inhibitor
- Antiproliferative, antitumor compound, anti-HIV and anti-aging compound
- Apoptosis enhancer and activator of autophagy
- Purity: ≥98%
Forms a complex with FKBP12 and inhibits the mammalian target of rapamycin (mTOR). Inhibits the response to interleukin-2 (IL-2), and thereby blocks activation of T and B cells. Potent immunosuppressant used as an alternative to calcineurin inhibitors. Restricts the proliferation of smooth-muscle cells by blocking cell cycle progression at the G1/S transition. Anti-proliferative. Antitumor compound. Activator of autophagy both in vitro and in vivo. Anti-HIV and anti-aging compound. Neuroprotective. Suppressor for self-renewal and vascular differentiation potential in hemangioma stem cells. Stability: Soluble in DMSO, methanol or chloroform. Stable for at least 2 years after receipt when stored at long term storage −20 °C. Short term storage at 4 °C.
White to off-white solid
Stable for at least two years after receipt when stored at -20°C.
Soluble in DMSO, methanol or chloroform.
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Formula:
C₅₁H₇₉NO₁₃ MW: 914.19 g/mol Storage Temperature: Freezer |
MDL Number:
MFCD00867594 CAS Number: 53123-88-9 |
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