1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one ≥98% (by TLC)
Supplier: Enzo Life Sciences
Synonyms:
ODQ
270-034-M010
270-034-M050
89147-098EA
106
USD
89147-098
89147-100
1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one ≥98% (by TLC)
1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one
Guanylyl cyclase inhibitor
ODQ is a potent and selective, direct-acting inhibitor of guanylate cyclase (IC50=20 nM). In cerebellar slices ODQ reversibly inhibited cGMP generation in response to endogenous NO or exogenously added NO-donors. ODQ does not inhibit NO-mediated macrophage toxicity (a phenomenon unrelated to cGMP) and does not inhibit particulate guanylyl cyclase or adenylyl cyclase. ODQ is an unique and selective tool to elucidate the physiological importance of the NO-cGMP pathway.
Formula:
C₉H₅N₃O₂ MW: 187.16 g/mol |
MDL Number:
MFCD00792620 CAS Number: 41443-28-1 |
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