1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one ≥98% (by TLC)

Supplier: Enzo Life Sciences

Synonyms: ODQ

270-034-M010 270-034-M050
89147-098EA 106 USD
89147-098 89147-100
1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one ≥98% (by TLC)
1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one

Guanylyl cyclase inhibitor


ODQ is a potent and selective, direct-acting inhibitor of guanylate cyclase (IC50=20 nM). In cerebellar slices ODQ reversibly inhibited cGMP generation in response to endogenous NO or exogenously added NO-donors. ODQ does not inhibit NO-mediated macrophage toxicity (a phenomenon unrelated to cGMP) and does not inhibit particulate guanylyl cyclase or adenylyl cyclase. ODQ is an unique and selective tool to elucidate the physiological importance of the NO-cGMP pathway.

Formula: C₉H₅N₃O₂
MW: 187.16 g/mol
MDL Number: MFCD00792620
CAS Number: 41443-28-1
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