You Searched For: Proteins and Peptides

Catalog Number: (10799-462)

Supplier: Rockland Immunochemical

Description: 14-3-3σ or stratifin is a protein that is strongly induced by gamma irradiation and other DNA-damaging agents (1). The induction of 14-3-3σ is mediated by a p53 responsive element. Exogenous introduction of 14-3-3σ into cycling cells results in a G2 cell cycle arrest (2). Knockout of 14-3-3σ in cells showed that the cells are unable to maintain cell cycle arrest after DNA damage. The 14-3-3σ -/- cells die as they enter mitosis. This process is associated with a failure of the 14-3-3σ-deficient cells to sequester the proteins that initiate mitosis and prevent them from entering the nucleus. Thus, 14-3-3σ plays an important role in maintaining the G2 checkpoint in cells and preventing mitotic death. 14-3-3σ Protein is ideal for investigators involved in Cell Stress& Chaperone Proteins, AKT/PKB Pathway, Cancer, Cell Cycle, Cellular Stress, ERK/MAPK Pathway, Neurobiology, PKA/PKC Pathway, and WNT Signaling research.

Catalog Number: (89164-156)

Supplier: Enzo Life Sciences

Description: Produced in insect cells. Full length active enzyme.

Supplier: MP Biomedicals

Description: Soluble in water or dilute aqueous buffer.

SDS

Supplier: Rockland Immunochemical

Description: Recombinant Human IGF-II control protein

Supplier: Rockland Immunochemical

Description: Recombinant Mouse Resistin Dimer control protein

Supplier: Enzo Life Sciences

Description: Isolated from human leukocytes. Negative for HBsAG-, HCV- and HIV-antibodies.££Haem protein that catalyzes oxidations by H2O2, including MPO-chloride-mediated killing of microbes and tumor cells, inactivation of chemotactic factors, cross-linking of proteins and iodination of proteins.

Catalog Number: (RL009-001-C23)

Supplier: Rockland Immunochemical

Description: Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as Tumor Angiogenesis Factor. Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth, vascular permeability, cell migration, and endothelial cell proliferation and growth, it may play a role in stimulating vasolidation via nitric oxide-dependent pathways and in inhibition of apoptosis. VEGF binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. Alternative splicing of the mRNA for VEGF-A results in several isoforms of the protein being produced. Rat and bovine VEGF are one amino acid shorter than the human factor, and the bovine and human sequences show a homology of 95 percent. In contrast to other factors mitogenic for endothelial cells such as FGF-1, FGF-2 and PDGF, VEGF is synthesized as a precursor containing a typical hydrophobic secretory signal sequence of 26 amino acids. Glycosylation is not required for efficient secretion of VEGF. VEGF121 is acidic, freely secreted, and widely expressed. This isoform is produced by alternative promoter usage and alternative initiation. It starts at an alternative upstream CUG codon and is post-translationally processed to produce the secreted VEGF peptide and a N-terminal peptide N-VEGF. The unprocessed protein and the N-VEGF peptide may localize to the nucleus, the endoplasmic reticulum and the Golgi or the extracellular matrix. Recombinant Human VEGF-121 produced in E.coli is a double, non-glycosylated, polypeptide chain containing 121 amino acids and having a molecular mass of 28423 Daltons.

Catalog Number: (75932-648)

Supplier: Rockland Immunochemical

Description: Tau-441 (151-391) control protein

Supplier: Rockland Immunochemical

Description: Apelin Control Peptide

Supplier: Rockland Immunochemical

Description: Recombinant Mouse LIF control protein

Supplier: Enzo Life Sciences

Description: Fluorogenic substrate cleaved by plasma kallikrein and kallikrein 8, but not plasmin; by papain; and by most cathepsins (cathepsins B, C/DPP-I, F, K/O2, L, L2/V, O, S, and X/Z). Ex.: 380 nm, Em.: 460 nm, although the following Ex/Em can also be used: 355,375/440,450. This substrate is useful for inhibitor screening and kinetic analysis. Also available: fluorogenic calibration standard AMC (BML-KI144).

Catalog Number: (76002-270)

Supplier: Enzo Life Sciences

Description: Produced in E. coli.

Supplier: MP Biomedicals

Description: Cytochrome c is an electron-carrying mitochondrial protein. The transition of Cytochrome c between the ferrous and ferric states within the cell makes it an efficient biological electron-transporter and it plays a vital role in cellular oxidations in both plants and animals. It is generally regarded as a universal catalyst of respiration, forming an essential electron-bridge between the respirable substrates and oxygen.

SDS

Supplier: Enzo Life Sciences

Description: Inhibitor of caspase-1, -4 and -5

Catalog Number: (TCG0427-5G)

Supplier: TCI America

Description: Product Categories: Bioscience, Oligopeptides
Other Product Names / Synonyms: Diglycine Benzyl Ester p-Toluenesulfonate, H-Gly-Gly-OBzl.Tos-OH

SDS

Catalog Number: (10801-984)

Supplier: Rockland Immunochemical

Description: BAG1 (also known as BCL2-associated athanogene) is a membrane protein rich in glutamic acid residues that binds to BCL2 and blocks apoptosis or programmed cell death (1). The BAG1-BCL2 complex enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms (2). Overexpression of BAG1 in 3T3 fibroblasts prevents apoptosis in the presence of low serum. BAG1 has also been shown to interact with activated glucocorticoid, androgen, estrogen and progesterone receptors. Binding to these receptors by BAG1 is dependent on receptor activation. BAG1 Protein is ideal for investigators involved in Signaling Proteins, Apoptosis Proteins, AKT/PKB Pathway, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, and Neurobiology research.