Anti-SIP1 Rabbit Polyclonal Antibody

Supplier: Rockland Immunochemical
600-401-EL0
75931-894EA 635.22 USD
75931-894
Anti-SIP1 Rabbit Polyclonal Antibody
Antibodies
SIP1 is one of the proteins found in the SMN complex, which consists of the survival of motor neuron (SMN) protein and several gemin proteins. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. SIP1 interacts directly with the SMN and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. However, knockdown of the SIP1 mRNA in motor neurons showed normalMore Product Information
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