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Image Unavailable-M-1530.0005BA

l-leucylglycylglycine

Catalog Number: (M-1530.0005BA)
Supplier: Bachem Americas
Description: Sequence: H-Leu-Gly-Gly-OH
Image Unavailable-M-1715.1000BA

Pz-Pro-Leu-Gly-Pro-D-Arg-OH Trifluoroacetate

Supplier: Bachem Americas
Description: See also M-2460 and M-2465.

Image Unavailable-M-2115.0001BA

Abz-Arg-Val-Lys-Arg-Gly-Leu-Ala-m-nitro-Tyr-Asp-OH Trifluoroacetate

Catalog Number: (M-2115.0001BA)
Supplier: Bachem Americas
Description: This internally quenched fluorogenic peptide substrate contains anthranilic acid as fluorescent donor and m-nitro-tyrosine as acceptor (quencher). The sequence Abz-RVKRGLAY(NO₂)E is based on the sequence of hemagglutinin. The FRET substrate is efficiently cleaved by furin, a subtilisin-like eukaryotic serine endoprotease with Km = 3.8 µM and kcat = 29.3 s⁻¹ (kcat/Km = 7'710'000 M⁻¹s⁻¹). Its kcat/Km value is over 2000-fold higher than that of the commonly used substrate Boc-Arg-Val-Arg-Arg-AMC (I-1645). FRET Substrate for the basic residue-specific yeast aspartyl protease yapsin 1.
Image Unavailable-M-2105.0005BA

Mca-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-NH₂ Trifluoroacetate

Supplier: Bachem Americas
Description: The FRET substrate Mca-RPKPYA-Nva-WMK(Dnp)-amide was hydrolyzed 60 times more rapidly by stromelysin 1 (MMP-3) (kcat/Km= 59400 M⁻¹s⁻¹) than by interstitial collagenase (MMP-1). However, it showed little discrimination between MMP-3, gelatinase A (MMP-2) (kcat/Km= 54000 M⁻¹s⁻¹), and gelatinase B (MMP-9) (kcat/Km= 55300 M⁻¹s⁻¹). Metalloelastase (MMP-12) digested this fluorogenic substrate with a kcat/Km of 243000 M⁻¹s⁻¹. For a fluorescent standard see M-2250.

Image Unavailable-M-1290.0001BA

(S)-Methyl-6-amino-2-(((benzyloxy)carbonyl)amino)hexanoate hydrochloride

Supplier: Bachem Americas
Description: Sequence: Z-Lys-OMe · HCl

Image Unavailable-M-1295.0250BA

Z-Lys-ONp hydrochloride

Supplier: Bachem Americas
Description: Sequence: Z-Lys-ONp · HCl

Image Unavailable-M-1895.0001BA

Mca-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH₂ Trifluoroacetate

Supplier: Bachem Americas
Description: Mca-PLGL-Dpa-AR-amide is a very sensitive FRET substrate for continuous assays and in situ determination of the matrix metalloproteinase activity. Cleavage at the Gly-Leu bond separates the highly fluorescent Mca group from the efficient 2,4-dinitrophenyl quencher, resulting in an increase in fluorescence intensity. The kcat/Km values for the punctuated metalloproteinase (MMP-7) and for gelatinase (MMP-2), e.g., are 1.7·10⁵ and 6.3·10⁵ M⁻¹s⁻¹, respectively.

Image Unavailable-M-1865.0001BA

DABCYL-gamma-Abu-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS Trifluoroacetate

Supplier: Bachem Americas
Description: This fluorogenic HIV-1 protease substrate consists of an octapeptide with a fluorescent donor (EDANS) and a quenching acceptor (DABCYL), attached at the COOH- and NH₂-termini. The γ-Abu spacer was inserted to avoid potential steric hindrance of substrate binding by the bulky acceptor. This FRET substrate is cleaved by the HIV-1 protease at the Tyr-Pro bond which results in a time-dependent increase in fluorescence intensity; excitation at 340 nm, emission at 490 nm.

Image Unavailable-M-1845.0250BA

FA-Gly-Phe-Leu-OH

Supplier: Bachem Americas
Description: The FA-peptides M-1400 and M-1410 are common ACE substrates and thus filed in the corresponding product family. For our 3-(2-furyl)acryloyl-amino acids (FA-amino acids) and the labeling reagent FA-OSu (Q-1245), please see the Amino Acids section.

Image Unavailable-M-2460.0001BA

Mca-Amyloid beta/A4 Protein Precursor₇₇₀ (667-676)-Lys(Dnp)-Arg-Arg amide Trifluoroacetate

Supplier: Bachem Americas
Description: This fluorescent (FRET) peptide substrate contains the wild-type amyloid precursor protein (APP) β-secretase cleavage site. Mca-SEVKMDAEFRK(Dnp)RR- amide has been used for assaying β-secretase-like activity of thimet oligopeptidase (TOP, EC 3.4.24.15). The results suggested that TOP is a potential β-secretase candidate and is involved in the processing of APP in vivo. See also L-1905.

Image Unavailable-M-2565.0005BA

Abz-(Asn⁶⁷⁰,Leu⁶⁷¹)-Amyloid beta/A4 Protein Precursor₇₇₀ (669-674)-EDDnp Trifluoroacetate

Supplier: Bachem Americas
Description: Intramolecularly quenched fluorescent substrate containing the ortho-aminobenzoyl (Abz) / N-(2,4-dinitrophenyl)ethylenediamine (EDDnp) groups as the donor / acceptor pair. It corresponds to the Swedish-mutated (JMV2236) β-amyloid precursor protein (βAPP) sequence targeted by β-secretase BACE (β-site APP-cleaving activity). This FRET substrate is more selectively cleaved by BACE1 and BACE2 than by cathepsin D, a disintegrin and metalloprotease 10 (ADAM10), tumor necrosis α-converting enzyme (TACE), presenilin-1 (PS1), or presenilin-2 (PS2).

Image Unavailable-C-1945.0025BA

N(α)-Cbz-L-histidine

Supplier: Bachem Americas
Description: Sequence: Z-His-OH

Image Unavailable-C-1745.0001BA

Z-Gly-Gly-Gly-Gly-OH

Catalog Number: (C-1745.0001BA)
Supplier: Bachem Americas
Description: Sequence: Z-Gly-Gly-Gly-Gly-OH
Image Unavailable-C-1710.0005BA

Z-Gly-Gly-OSu

Supplier: Bachem Americas
Description: Sequence: Z-Gly-Gly-OSu

Image Unavailable-I-1840.0250BA

Z-Val-Ala-Asn-AMC

Supplier: Bachem Americas
Description: Substrate for the determination of a new cysteine endopeptidase which is required for antigen processing. Z-VAN-AMC has been used as a fluorogenic substrate for porcine asparaginyl endopeptidase (AEP, legumain).

Image Unavailable-I-1955.0005BA

Ac-Arg-Leu-Arg-AMC Trifluoroacetate

Supplier: Bachem Americas
Description: Substrates for measuring the chymotryptic, PGPH, and tryptic acitivity of the 20S or 26S proteasome. See also the thrombin substrate I-1140.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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  • State issued document with your organization's Federal Tax ID Number
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* ATTN: California Customers may require additional documentation as part of the CA Health & Safety Code. Products that fall under this regulation will be placed on a mandatory 21-day hold after documentation is received. VWR will not lift restrictions for residential shipping addresses.

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This product has been blocked by your organization. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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