You Searched For: SOUTHERN BIOTECHNOLOGY MS

Catalog Number: (100244-736)

Supplier: Southern Biotechnology

Description: Purified Goat Anti-Rabbit IgM antibody for use in ELISA, flow cytometry, immunohistochemistry, western blotting, ELISpot, and separation assays.

Catalog Number: (101442-826)

Supplier: Southern Biotechnology

Description: AP Anti-Rat IgG2a antibody for use in ELISA, immunohistochemistry, and ELISpot assays.

Catalog Number: (100241-952)

Supplier: Southern Biotechnology

Description: Purified Mouse IgG3 for use as a control in flow cytometry, immunocytochemistry, immunoprecipitation, and in vitro assays and as a standard in ELISA.

Catalog Number: (100241-978)

Supplier: Southern Biotechnology

Description: Mouse IgA-PE/CY5 (SPRD) for use as a control in flow cytometry assays.

Catalog Number: (100242-350)

Supplier: Southern Biotechnology

Description: Purified Anti-Human IL-13 antibody for use in flow cytometry, immunohistochemistry / immunocytochemistry, ELISA, and ELISpot assays.

Catalog Number: (100241-992)

Supplier: Southern Biotechnology

Description: Mouse IgG-PE for use as a control in flow cytometry assays.

Catalog Number: (100242-138)

Supplier: Southern Biotechnology

Description: Hamster IgG-Biotin for use as a control in flow cytometry assays.

Catalog Number: (100242-152)

Supplier: Southern Biotechnology

Description: Hamster IgG-PE/CY7 for use as a control in flow cytometry assays.

Catalog Number: (100241-986)

Supplier: Southern Biotechnology

Description: Mouse IgG-FITC for use as a control in flow cytometry and immunohistochemistry / immunocytochemistry assays.

Catalog Number: (100242-678)

Supplier: Southern Biotechnology

Description: Goat Anti-Mouse IgG2a-AP antibody with minimal reactivity to human proteins for use in ELISA, immunohistochemistry / immunocytochemistry, western blotting, and ELISpot assays.

Catalog Number: (100242-726)

Supplier: Southern Biotechnology

Description: Purified Goat F(ab’)2 Anti-Mouse IgG2b antibody with minimal reactivity to human proteins for use in ELISA, flow cytometry, and immunocytochemistry assays.

Catalog Number: (100242-732)

Supplier: Southern Biotechnology

Description: Goat F(ab’)2 Anti-Mouse IgG2b-PE antibody with minimal reactivity to human proteins for use in flow cytometry assays.

Catalog Number: (100243-332)

Supplier: Southern Biotechnology

Description: CD24, also known as heat stable antigen, is a phosphatidylinositol-linked cell surface glycoprotein that is expressed at all stages of B cell development and on most thymocytes. The absence of expression from mature T cells is closely associated with their maturation from CD4+CD8+CD24+ thymocytes to either CD4+CD8-CD24- or CD4-CD8+CD24- T cells. CD24 is also present on mouse granulocytes, monocytes, Langerhans cells and erythrocytes. Its ligand is P-selectin (CD62P). CD24 may play a role in regulation of B cell proliferation and differentiation, and it has been proposed that heat stable antigen promotes homotypic adhesion between B lymphocytes.

Supplier: Southern Biotechnology

Description: The CD23 antigen is the low affinity IgE Fc receptor, which is a 45-49 kDa protein with 38 and 28 kDa fragments. It is expressed on most mature, conventional B cells (but not on peritoneal CD5+ B cells) and can also be found on the surface of T cells, macrophages and platelets. It is distinct from the high affinity IgE receptors found on basophils and mast cells which mediate allergic reactions. The low affinity receptors are thought to play a role in isotype specific immunoregulation. The regulation of CD23 surface expression appears to be integral with the complex IgE system which involves interactions of cells, cytokines, antibodies and regulatory factors. CD23 has been described as a “membrane bound cytokine," in that the soluble cleavage products of CD23 are themselves able to act as cytokines in vitro.

Catalog Number: (100243-600)

Supplier: Southern Biotechnology

Description: CD62L, also known as L-selectin, is a type I transmembrane glycoprotein with lectin-like and epidermal growth factor-like domains. It binds to sialylated oligosaccharide determinants on high endothelial venules (HEV) in peripheral lymph nodes. In the mouse, CD62L is expressed on most thymocytes and on peripheral leukocytes, including B and T lymphocytes, neutrophils, monocytes, and eosinophils. This member of the selectin family of cell adhesion molecules appears to be required for lymphocyte homing to peripheral lymph nodes and for leukocyte extravasation at sites of inflammation. Expression of CD62L on lymphocytes and neutrophils is rapidly down-regulated upon cell activation and the level of CD62L expression, along with other markers, distinguishes naive T cells from effector/memory T cells. The monoclonal antibody MEL-14 blocks in vitro binding of lymphocytes to peripheral lymph node HEV and inhibits in vivo lymphocyte extravasation into peripheral lymph nodes and the late stages of leukocyte rolling.

Supplier: Southern Biotechnology

Description: CD3ε, a member of the immunoglobulin superfamily of cell surface receptors, is comprised of five invariable chains ranging in size from 16-28 kDa and is closely associated with the T cell antigen receptor (TCR). It is expressed on all T cells of all mouse strains. CD3 plays a major role in signaling during antigen recognition, leading to T-cell activation. The 145-2C11 monoclonal antibody recognizes an epitope on the 25 kDa ε chain of the CD3/TCR complex. In the presence of Fc receptor-bearing accessory cells, soluble 145-2C11 can activate primed and naïve T cell in vitro. 145-2C11 can also induce redirected lysis of specific target cells by CTL clones and it can block lysis of specific target cells by antigen-specific CTL’s. Immobilized 145-2C11 can activate both normal T lymphocytes and cloned T cell lines. Under certain conditions, T cell activation by 145-2C11 may result in apoptotic cell death.