You Searched For: Enzo Life Sciences

Supplier: Enzo Life Sciences

Description: HDAC inhibitor

Catalog Number: (89156-984)

Supplier: Enzo Life Sciences

Description: A novel member of the spiro-piperidine class of M2 proton channel inhibitors similar to BL-1743. Displays increased potency (IC50=0.92µM) compared with amantadine.

Catalog Number: (89156-652)

Supplier: Enzo Life Sciences

Description: Highly specific substrate for the caspase-like peptidic activity of the 20S proteasome.

Supplier: Enzo Life Sciences

Description: PP2A inhibitor

Supplier: Enzo Life Sciences

Description: Plant alkaloid

Catalog Number: (89164-430)

Supplier: Enzo Life Sciences

Description: alpha-defensins purified from human neutrophils. Defensins are short peptides secreted by neutrophils and epithelial cells as proproteins and activated by proteolysis. They have antibacterial, antiviral, and antifungal properties, and they promote immune response. Can be used in tissue culture or in vivo.

Supplier: Enzo Life Sciences

Description: Host: Mouse, Isotype: IgG1

Catalog Number: (89163-882)

Supplier: Enzo Life Sciences

Description: Produced in <i>E. coli</i>. Full length human caspase-9 (aa 1-416).

Catalog Number: (89158-298)

Supplier: Enzo Life Sciences

Description: Liquid. In 50mM TRIS-Cl, pH 7.5, containing 0.1M ATP and 0.1M MgCl2.

Supplier: Enzo Life Sciences

Description: A novel NO donor which only releases NO in the presence of thiols. It is a potent vasodilator and inhibitor of platelet aggregation.

Supplier: Enzo Life Sciences

Description: Monomeric G-protein Ras functions as a molecular switch linking receptor and nonreceptor tyrosine kinase activation to a number of downstream signaling pathways. Oncogenic mutations, which occur in approximately 30% of all cases of human cancer, lead to the stimulation of proliferation and the inhibition of apoptosis.

SDS

Catalog Number: (89154-480)

Supplier: Enzo Life Sciences

Description: Capases are a highly conserved family of cysteine proteases and are synthesized as inactive zymogens, which are cleaved at Asp-x sites during apoptosis, generating large and small subunits that heterodimerize to form the active enzyme. Caspase-1 is a member of the ICE/CED-3 family of caspases and is detected in the pro-form as a protein of 45 kDa.
Caspase-1 generates the bioactive form of the pro-inflammatory cytokine IL-1β from its biologically inactive precursor. Overexpression of caspase-1 in cells induces apoptosis, which can be inhibited by cytokine response modifier A (CrmA). Caspase-1 mRNA is predominantly expressed in the spleen and lung and to a lesser extent in skeletal muscle, kidney, testis and heart and within these tissues macrophages preferentially express caspase-1. Caspase-1 deficient mice have no gross abnormalities, however, macrophages from caspase-1-deficient mice are defective in IL-β processing and release.

Supplier: Enzo Life Sciences

Description: TRIP-Br1 (SEI-1) functions as physiological integrator of transcriptional regulatory signals at E2F-responsive promoters to ensure proper execution of E2F-dependent cell cycle progression. TRIP-Br1 is defined as an oncogene.

Supplier: Enzo Life Sciences

Description: MRN inhibitor

Catalog Number: (89151-694)

Supplier: Enzo Life Sciences

Description: Produced in <i>E. coli.</i> The extracellular domain of mouse TNF-α (tumor necrosis factor-α) (aa 77-235) is fused at the N-terminus to a linker peptide (8 aa) and a FLAG®-tag.

Catalog Number: (89147-814)

Supplier: Enzo Life Sciences

Description: Cell permeable, potent, selective and ATP-competitive inhibitor of CDK2/cyclin A (IC50=22nM), CDK1/cyclin B (IC50=40nM) and CDK4/cyclin D1 (IC50=200nM). Has no effect on the activity of PKC, p38, PDGFRβ and EGFR (IC50>10µM). Displays anti-proliferative and pro-apoptotic properties in tumor cells. Inhibits proliferation of growth factor-stimulated colon carcinoma cells by binding to CDK2 and thus preventing the phosphorylation of pRb and its dissociation from E2F.