You Searched For: Antibodies

Catalog Number: (75928-180)

Supplier: Rockland Immunochemical

Description: GPR3, also known as ACCA, is a G-protein coupled receptor that constitutively activates adenylate cyclase and is highly expressed in the central nervous system. Overexpression of GPR3 stimulates the production of amyloid-beta peptide (Abeta), the deposition of which is one of the pathological hallmarks of Alzheimer 's disease (AD), while the ablation of GPR3 prevented the accumulation of Abeta in vitro and in an AD mouse model. This is of particular interest because of the proximity of a reported candidate Alzheimer 's disease (AD) locus, suggesting that GPR3 may be a potential therapeutic target for the treatment of AD. GPR3 has also been shown to block the proliferation of cerebellar granule cell precursors (GCP) during postnatal development by inhibiting the Shh-induced proliferation of GCP, indicating that GPR3 activation may represent one of the signals that triggers the postnatal cell cycle exit and terminal differentiation of GPCs.

Catalog Number: (75928-158)

Supplier: Rockland Immunochemical

Description: Anti-Golden Syrian Hamster IgG Cy5.5 Antibody generated in goat detects Golden Syrian Hamster IgG. Secreted as part of the adaptive immune response by plasma B cells, immunoglobulin G constitutes 75% of serum immunoglobulins. Immunoglobulin G binds to viruses, bacteria, as well as fungi and facilitates their destruction or neutralization via agglutination (and thereby immobilizing them), activation of the compliment cascade, and opsinization for phagocytosis. The whole IgG molecule possesses both the F(c) region, recognized by high-affinity Fc receptor proteins, as well as the F(ab) region possessing the epitope-recognition site. Both heavy and light chains of the antibody molecule are present. Secondary Antibodies are available in a variety of formats and conjugate types. When choosing a secondary antibody product, consideration must be given to species and immunoglobulin specificity, conjugate type, fragment and chain specificity, level of cross-reactivity, and host-species source and fragment composition.

Catalog Number: (75934-288)

Supplier: Rockland Immunochemical

Description: Thymic stromal lymphopoietin (TSLP) has recently been identified as an important factor capable of driving dendritic cell maturation and activation. It is involved in the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and the induction of CD4+ T cell-mediated allergic reaction. TSLP is also capable of supporting the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development. Its receptor TSLP-R will bind TSLP in a low-affinity fashion in transfected cells; co-transfection with IL-7R-alpha cDNA results in high-affinity binding and a functional heteromeric complex. This heteromeric receptor requires stat5 for TSLP-mediated signal transduction and is inhibited by SOCS-1. The approximately 75 kDa band seen in the immunoblot may be a post-translationally modified form of TSLP-R.

Catalog Number: (75934-306)

Supplier: Rockland Immunochemical

Description: ZBTB1 is a zinc finger protein that also contains BTB (BR-C, ttk and bab) domain. While little is known about this protein or the related protein ZBTB2, its expression is known to be down-regulated in human bronchial epithelial cells in response to the presence of Vanadium. Recently, expression of variant ZBTB1 protein has been associated with increased age-related macular degeneration.

Catalog Number: (75934-308)

Supplier: Rockland Immunochemical

Description: ZBTB2 is a zinc finger protein that also contains BTB (BR-C, ttk and bab) domain. While little is known about this protein or the related protein ZBTB1, ZBTB2 is thought to be phosphorylated in response to the DNA damage, probably by either ATM or ATR. At least two isoforms of ZBTB2 are known to exist.

Catalog Number: (75934-290)

Supplier: Rockland Immunochemical

Description: The tetraspan family protein members are characterized by four predicted transmembrane domains and are thought to be involved in physiological processes such as tissue differentiation, immunological responses, and sperm-egg fusion. TSPAN9 has recently been identified as a platelet tetraspanin and a component of tetraspanin microdomains that include the collagen receptor GPVI (glycoprotein VI) and integrin alpha6beta1 but not the von Willebrand receptor GPIb alpha or the integrins alphaIIb beta3 or alpha2 beta1, suggesting that TSPAN9 may act to regulate platelet function in concert with other tetraspanins and their associated proteins.

Catalog Number: (75933-926)

Supplier: Rockland Immunochemical

Description: Anti-Mouse IgG F(c) DyLight antibody generated in rabbit is a proteolytic fragment of immunoglobulin G (IgG) obtained by limited digestion with the enzyme papain under controlled conditions of temperature, time and pH. Receptors bind the Fc portion of mouse IgG and often this fragment is removed from immunoglobulins to minimize receptor binding and lower background reactivity.

Supplier: Tonbo Biosciences

Description: The 2.4G2 antibody is specific for a common epitope found in the extracellular regions of mouse Fc-receptors Fc-gamma II (CD32) and Fc-gamma III (CD16). These receptors are expressed by B cells, monocytes, macrophages, NK cells, dendritic cells, and neutrophils.

Catalog Number: (76040-216)

Supplier: Tonbo Biosciences

Description: Rabbit anti-Mouse IgG (H&L) - Affinity Pure

Catalog Number: (76040-188)

Supplier: Tonbo Biosciences

Description: Goat anti-Mouse IgM (H&L) - Affinity Pure, Biotin Conjugate

Catalog Number: (76040-250)

Supplier: Tonbo Biosciences

Description: Goat anti-Human IgG (H&L) - Affinity Pure, HRP Conjugate, min x w/bovine, mouse or rabbit serum proteins

Catalog Number: (76040-226)

Supplier: Tonbo Biosciences

Description: Sheep anti-Rabbit IgG (H&L) - Affinity Pure

Catalog Number: (76040-212)

Supplier: Tonbo Biosciences

Description: Rabbit anti-Human IgM (mu chain) - Affinity Pure, Biotin Conjugate

Catalog Number: (76040-378)

Supplier: Tonbo Biosciences

Description: Goat anti-Rat IgG (H&L) - Affinity Pure, HRP Conjugate

Catalog Number: (76002-642)

Supplier: Enzo Life Sciences

Description: Recommended Applications: Flow Cytometry, IHC (PS), FUNC

Species reactivity: Human

Catalog Number: (76002-758)

Supplier: Enzo Life Sciences

Description: Recommended Applications: Flow Cytometry, IHC (FS)

Species reactivity: Human, Sheep