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n-Pentane, Uvasol® for spectroscopy, Supelco®

Catalog Number: (EM1.07179.1000)

Supplier: MilliporeSigma

Description: Accurate analytic results in UV/VIS and infrared spectroscopy depend on the use of very pure solvents for sample preparation. The Uvasol® solvents range has been specially designed for spectroscopy and other applications requiring solvents of the highest spectral purity. The refinement process allows a greater degree of security in applications and avoids misinterpretation of analytical results caused by traces of UV, IR and fluorescence contamination. Uvasol® solvents offer best UV transmittance. In all specifications the minimum transmittance for 5 typical wavelengths are identified. Furthermore the transmittance is specified in accordance with Reag. Ph Eur and ACS.

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Toluene, Uvasol® for spectroscopy, Supelco®

Catalog Number: (EM1.08331.1000)

Supplier: MilliporeSigma

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Tetrahydrofuran, Uvasol® for spectroscopy, Supelco®

Supplier: MilliporeSigma

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Acetonitrile, Uvasol® for spectroscopy, Supelco®

Supplier: MilliporeSigma

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Ethyl acetate, Uvasol® for spectroscopy, Supelco®

Supplier: MilliporeSigma

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tert-Butyl methyl ether, Uvasol® for spectroscopy, Supelco®

Catalog Number: (EM1.01984.1000)

Supplier: MilliporeSigma

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Anti-INS Mouse Monoclonal Antibody (CF680R) [clone: IRDN/794]

Supplier: Biotium

Description: This antibody recognizes a polypeptide which is identified as insulin, a 51-amino acid polypeptide composed of A and B chains connected through the C-peptide. Proinsulin, which has very little biological activity, is cleaved by proteases within its cell of origin into the insulin molecule and the C-terminal basic residue. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids. Deficiency of insulin results in diabetes mellitus. The main storage site for insulin is the pancreatic islets. Antibodies to insulin are important as beta-cell and insulinoma marker.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®680R is a near-infrared fluorescent dye (Ex/Em 680/701 nm) with unrivaled photostability. It also is validated in super-resolution imaging by STED and single-molecule spectroscopy.

Anti-CD3E Mouse Monoclonal Antibody (CF680R) [clone: RIV9]

Supplier: Biotium

Description: This antibody reacts with five invariable CD3 chains designated CD3y, CD3d, CD3e, CD3f, and CD3n with molecular weight ranging from 16-28 kDa. It is found on all mature T-lymphocytes, NK, T-cells, and some thymocytes. CD3, also known as T3, is a member of the immunoglobulin superfamily that plays a role in antigen recognition, signal transduction, and T cell activation. It is expressed, typically at high levels, on peripheral T cells and majority of T cell neoplasms. Thymocytes express CD3 at different level on the cell surface in the course of differentiation and, in cortical thymus, CD3 is predominantly intracytoplasmic. This MAb is particularly useful for induction of T cell activation in vitro and in vivo due to its unusual IgG3 isotype.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®680R is a near-infrared fluorescent dye (Ex/Em 680/701 nm) with unrivaled photostability. It also is validated in super-resolution imaging by STED and single-molecule spectroscopy.

beta-Amyloid (1-42)

Supplier: Bachem Americas

Description: Aβ 1-42, 42-residue fragment of amyloid precursor protein, has been found to be a major constituent of the senile plaques formed in the brains of patients with Alzheimer's disease and late Down's syndrome. Aβ 1-42 readily forms neurotoxic oligomers at physiological pH. On the other hand, the peptide shows antimicrobial activity. The sequence of H-1368 corresponds to the human, bovine, canine, feline, ovine, guinea pig, and rabbit Aβ42 peptide. The peptide has been used to detect amyloid β-protein multimers in the cerebrospinal fluid of Alzheimer's disease patients through fluorescence correlation spectroscopy. For detailed descriptions of the preparation of Aβ 1-42 monomers and protofibrils please see the papers of Jan, Hartley, and Lashuel, Stine et al. (2011), and of Broersen and colleagues. The findings of Ryan et al. indicate that 10% ammonia disaggregates Aβ42 more efficiently than HFIP.

Anti-TGM2 Mouse Monoclonal Antibody (CF680R) [clone: TGM2/419]

Supplier: Biotium

Description: This antibody recognizes a 77-85 kDa protein, identified as cellular or tissue transglutaminase II (TGase II). Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. The identification of transglutaminase as the main antigen of endomysium antibodies allows a new diagnostic approach to celiac disease (CD), a genetic, immunologically mediated small bowel enteropathy that causes malabsorption. TGase II is implicated in programmed cell death, signal transduction, drug-resistance, cell growth, endocytosis, insulin secretion, cell adhesion, cataract formation, and wound healing.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®680R is a near-infrared fluorescent dye (Ex/Em 680/701 nm) with unrivaled photostability. It also is validated in super-resolution imaging by STED and single-molecule spectroscopy.

X-Ray Mix Additive, Chemplex®, tablets

Supplier: Chemplex

Description: Highly “plasticizes” and firmly bonds samples together under briquetting pressure

X-Ray Mix Additive, Chemplex®, powder

Catalog Number: (15566-072)

Supplier: Chemplex

Description: Highly “plasticizes” and firmly bonds samples together under briquetting pressure

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Chloroform-[D₁] (99.8% D) + 0.03% TMS for NMR spectroscopy

Supplier: VWR International

Description: Deuterium Labeled Compounds. These high-quality products are used as solvents in NMR spectroscopy, R&D, tracers, and building blocks in pharmaceutical ingredients, as well as for the synthesis of organic light-emitting diodes (OLED).

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