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Two-Piece Jacketed Pressure Reactor without Drain Valve, Ace Glass Incorporated

Supplier: Ace Glass

Description: Complete, two-piece, jacketed flask pressure reactor system designed to perform low to moderate positive pressure reactions, synthesis, and catalysis. Reactor capacities range from 500mL to 5000mL, and use Ace-Threds to achieve a leak-tight system. Two-piece (Duran® flanged flask and head) design allows the use of large agitators and facilitates product removal and clean-out. Systems can be selected with either a shaft and agitator style mixing, or stir bar mixing with the use of a super magnet suspended below the reactor body. Reactor bodies are available with 28/15 ball joint or Ace-Thred inlet and outlets. Does not include stand.

Anti-RAG2 Rabbit Polyclonal Antibody

Catalog Number: (10092-944)

Supplier: Proteintech

Description: Recombination activating gene 2(RAG2) is core part of the RAG complex(RAG1 and RAG2), which mediates the DNA cleavage phase during V(D)J recombination. The RAG complex also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. The introduction of DNA breaks by the RAG complex on one immunoglobulin allele induces ATM-dependent repositioning of the other allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. In the RAG complex, RAG2 is not the catalytic component but is required for all known catalytic activities mediated by RAG1. It probably acts as a sensor of chromatin state that recruits the RAG complex to H3K4me3

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Mouse/Rat Restrainers

Supplier: WORLD PRECISION INSTRUMENTS LLC

Description: Mouse/rat restrainer for use with the non-invasive blood pressure system.

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Masterflex® L/S® Single-Use Gamma-Irradiated Pump Tubing, Avantor®

Supplier: VWR International

Description: Reduce the risk of microbial contamination.

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High Pressure Controller

Catalog Number: (77093-406)

Supplier: Lighthouse Worldwide

Description: The High Pressure Controller is used in conjuction with the Solair 1100 to sample high pressure gasses.

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Pressure Reactor Moisture Test Receiver, Ace Glass Incorporated

Supplier: Ace Glass

Description: Used to determine heavier-than-water, co-distilling solvent component content of reaction mixture

Anti-XPC Rabbit Polyclonal Antibody

Catalog Number: (10451-498)

Supplier: Bioss

Description: Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.

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Anti-XPC Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (76118-502)

Supplier: Bioss

Description: Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. <i>in vitro</i>, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.

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Hydro AccuMax Dilution System, 1-Button Dilution, High Flow

Catalog Number: (77007-812)

Supplier: Unimed-Midwest

Description: Systems using AccuPro pressure regulation technology eliminate dilution variance by controlling the water pressure into the unit, never allowing the dilution to 'lean out' the desired dilution target.

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Pressure Sensitive Vinyl Pipe Marker- 'Directional Arrows', National Marker

Supplier: ACCUFORM MANUFACTURING, INC

Description: Use on wet, oily and dusty pipes where pressure sensitive vinyl markers won't hold

Masterflex® Single-Use Bag Port Disc Opposing Barb, Avantor®

Supplier: VWR International

Description: Designed for sample port and dip tube applications.

Phenol Red Sucrose Broth

Supplier: VWR International

Description: A basal medium containing a single carbohydrate used to determine whether bacteria can ferment the specific carbohydrate. The medium contains a pH indicator that changes from red to yellow if the bacteria can ferment the carbohydrate.