MK-2 Inhibitor III hydrate ≥97% (by HPLC), Calbiochem®, Sigma-Aldrich®
Supplier: MilliporeSigma
Synonyms:
MK-2 Inhibitor III
, 2-(2-(Quinolin-3-yl)pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one hydrate
, 2-(2-Quinolin-3-ylpyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo-[3,2-c]pyridin-4-one hydrate
, MK2-IN-3 hydrate
M-Clarity™ quality level = MQ100
The MK-2 Inhibitor III, also referenced under CAS 1186648-22-5, controls the biological activity of MK-2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
General description
A cell-permeable pyrrolopyridinyl compound that acts as a potent, selective, and ATP-biniding site-targeting MK-2/MAPKAP-K2 inhibitor (IC50 = 8.5, 81, and 210 nM agaisnt MK-2, MK-5, and MK-3, respectively), while exhibiting much less or no activity against 8 other commonly studied kinases. Shown to suppress LPS-induced TNF-α production in U937 cells (IC50 = 4.4 µM).
A cell-permeable pyrrolopyridinyl compound that acts as an ATP-competitive inhibitor of MK-2/MAPKAP-K2 (IC50 = 8.5, 81, and 210 nM against MK-2, MK-5, and MK-3, respectively), while exhibiting much less or no activity against 8 other commonly studied kinases. Shown to suppress LPS-induced TNF-α production in U937 cells (IC50 = 4.4 µM).
Packaging: Packaged under inert gas
Formula:
C₂₁H₁₆N₄O·xH₂O MW: 340.38 g/mol (anhy) Storage Temperature: Refrigerator |
MDL Number:
MFCD28143748 CAS Number: 1186648-22-5 |
Learn more
About VWR
Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...