MK-2 Inhibitor III hydrate ≥97% (by HPLC), Calbiochem®, Sigma-Aldrich®

Supplier: MilliporeSigma

Synonyms: MK-2 Inhibitor III2-(2-(Quinolin-3-yl)pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one hydrate2-(2-Quinolin-3-ylpyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo-[3,2-c]pyridin-4-one hydrateMK2-IN-3 hydrate

M-Clarity™ quality level = MQ100

475864-5MG
82603-174EA 346.29 USD
82603-174
MK-2 Inhibitor III hydrate ≥97% (by HPLC), Calbiochem®, Sigma-Aldrich®
MK-2 Inhibitor III hydrate

The MK-2 Inhibitor III, also referenced under CAS 1186648-22-5, controls the biological activity of MK-2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.


General description
A cell-permeable pyrrolopyridinyl compound that acts as a potent, selective, and ATP-biniding site-targeting MK-2/MAPKAP-K2 inhibitor (IC50 = 8.5, 81, and 210 nM agaisnt MK-2, MK-5, and MK-3, respectively), while exhibiting much less or no activity against 8 other commonly studied kinases. Shown to suppress LPS-induced TNF-α production in U937 cells (IC50 = 4.4 µM).


A cell-permeable pyrrolopyridinyl compound that acts as an ATP-competitive inhibitor of MK-2/MAPKAP-K2 (IC50 = 8.5, 81, and 210 nM against MK-2, MK-5, and MK-3, respectively), while exhibiting much less or no activity against 8 other commonly studied kinases. Shown to suppress LPS-induced TNF-α production in U937 cells (IC50 = 4.4 µM).


Packaging: Packaged under inert gas

Formula: C₂₁H₁₆N₄O·xH₂O
MW: 340.38 g/mol (anhy)
Storage Temperature: Refrigerator
MDL Number: MFCD28143748
CAS Number: 1186648-22-5

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