Rapamycin ≥99% (by HPLC), Sigma-Aldrich®

Supplier: MilliporeSigma

Synonyms: (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone

553210-100UG 553210-1MG 553210-100UG 553210-1MG

80054-246EA 521.39 USD

80054-246 CA80054-244 80054-244 CA80054-246

Rapamycin ≥99% (by HPLC), Sigma-Aldrich®

Rapamycin

Antifungal and immunosuppressant

Clear film

Selectively inhibits the phosphorylation and activation of p70 S6 kinase (IC50=50pM). Prevents the translational activation of IGF-II. Shown to inhibit later signaling events such as p110Rb phosphorylation, p34cdc2 kinase activation and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Reported to induce apoptosis in a murine B cell line, to inhibit lymphokine-induced cell proliferation at the G1 phase and to irreversibly arrest Saccharomyces cerevisiae cells in the G1 phase.

Soluble in DMSO or MeOH

Formula: C₅₁H₇₉NO₁₃
MW: 914.19 g/mol

MDL Number: MFCD00867594
CAS Number: 53123-88-9

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