1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one, Calbiochem®

Supplier: MilliporeSigma

Synonyms: ODQ

495320-10MG 495320-10MG
80053-478EA 229.95 USD
CA80053-478 80053-478
1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one, Calbiochem®
1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one

A potent and selective inhibitor of nitric oxide (NO)-sensitive guanylyl cyclase (IC50=20nM)


In incubated cerebellum slices, ODQ reversibly inhibits the NO-dependent cGMP response to glutamate receptor agonists without affecting NOS activity. It does not chemically inactivate NO; however, it does inhibit cGMP generation in response to NO donors. ODQ does not inhibit NO-mediated macrophage toxicity, a phenomenon unrelated to cGMP, nor does it affect the activity of particulate guanylyl cyclase or adenylyl cyclase.

Formula: C₉H₅N₃O₂
MW: 187.16 g/mol
MDL Number: MFCD00792620
CAS Number: 41443-28-1

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