1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one, Calbiochem®
Supplier: MilliporeSigma
Synonyms:
ODQ
495320-10MG
495320-10MG
80053-478EA
229.95
USD
CA80053-478
80053-478
1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one, Calbiochem®
1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one
A potent and selective inhibitor of nitric oxide (NO)-sensitive guanylyl cyclase (IC50=20nM)
In incubated cerebellum slices, ODQ reversibly inhibits the NO-dependent cGMP response to glutamate receptor agonists without affecting NOS activity. It does not chemically inactivate NO; however, it does inhibit cGMP generation in response to NO donors. ODQ does not inhibit NO-mediated macrophage toxicity, a phenomenon unrelated to cGMP, nor does it affect the activity of particulate guanylyl cyclase or adenylyl cyclase.
Formula:
C₉H₅N₃O₂ MW: 187.16 g/mol |
MDL Number:
MFCD00792620 CAS Number: 41443-28-1 |
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