Anti-MSH6 Mouse Monoclonal Antibody [clone: 44]

Supplier: Diagnostic BioSystems

MOB429-01-RUO MOB429-05-RUO MOB429-05 MOB429 MOB429-01 MOB429-RUO
76633-890EA 800.81 USD
CA76633-890 76633-890 CA76633-888 76633-888 CA76633-886 76633-886
Anti-MSH6 Mouse Monoclonal Antibody [clone: 44]
Antibodies
MSH6 is a heterodimer of MSH2 and binds to DNA containing G/T mismatches. The MSH2-MSH6 complex recognizes a single-base mispair insertion/deletion loop. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. Studies have shown the mutations of MLH-1, MSH2 and MSH6 genes contribute to the development of sporadic colorectal carcinoma. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time.
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