SMPH (Succinimidyl-6-((beta-maleimidopropionamido)hexanoate), Pierce™

Supplier: 0000013509

Synonyms: SMPH

22363 22363
PI22363EA 316.62 USD
CAPI22363 PI22363
SMPH (Succinimidyl-6-((beta-maleimidopropionamido)hexanoate), Pierce™
SMPH (Succinimidyl-6-((beta-maleimidopropionamido)hexanoate)

Thermo Scientific Pierce SMPH is an amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a long spacer arm (14.2 angstroms).


  • Reactive groups: NHS ester and maleimide
  • Reactive towards: amino and sulfhydryl groups
  • Slightly longer and more soluble than SMPB
  • NHS ester reacts with primary amines at pH 7-9, forming a stable amide bond
  • Maleimide reacts with -SH groups at pH 6.5-7.5, forming a stable thioether bond
  • Non-cleavable
  • Water-insoluble (dissolve first in DMF or DMSO)


Caution: For Research Use Only. Not for use in diagnostic procedures.

Formula: C₁₇H₂₁N₃O₇
MW: 379.36 g/mol
Storage Temperature: Refrigerator
MDL Number: MFCD01863460
CAS Number: 367927-39-7

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Specification Test Results

Product Line Pierce™
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Reactive Moiety Maleimide, NHS Ester
Spacer Long
Form Powder
Quantity 50 mg
Type Crosslinker
Solubility DMF, DMSO

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