Anti-MCL1 Rabbit Polyclonal Antibody

Supplier: Rockland Immunochemicals

Anti-MCL-1 (rabbit) antibody 100 µg

Anti-MCL-1 (rabbit) antibody 100 µg

200-401-CR9

75929-884EA 635.22 USD

75929-884

Anti-MCL1 Rabbit Polyclonal Antibody

Antibodies

Myeloid cell leukimia-1 (Mcl-1) is a member of the Bcl-2 family of proteins that can act to promote cell survival. While the mechanism by which Mcl-1 inhibits apoptosis is not known, it is thought that it may heterodimerize and neutralize pro-apoptotic members of the Bcl-2 family such as Bim or Bak. Mcl-1 was originally identified in differentiating myeloid cells, but has since been shown to be expressed in multiple cell types. Mcl-1 is essential for embryogenesis and for the development and maintenance of B and T lymphocytes in animals. Mcl-1 exists as at least three distinct isoforms designated Mcl-1L, Mcl-1S and Mcl-1ES. In marked contrast to the larger isoform of Mcl-1, overexpression of Mcl-1S promotes cell death.

Anti-Mcl-1 Antibody has been tested for use in ELISA, Western Blotting, Immunocytochemistry and Immunofluorescence. Specific conditions for reactivity should be optimized by the end user. Expect a band at approximately 37 kDa in Western Blots of specific cell lysates and tissues.

Type: Primary
Antigen: MCL1
Clonality: Polyclonal
Clone:
Conjugation:
Epitope:
Host: Rabbit
Isotype:
Reactivity:

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