DMNPE-caged Luciferin

Supplier: OZ Biosciences

Synonyms: D-Luciferin 1-(4,5-dimethoxy-2-nitrophenyl)ethyl ester

Packaged under nitrogen.

LC10000 LC50000 LC25000
103549-586EA 420.4 USD
103549-586 103549-584 103549-590
DMNPE-caged Luciferin
DMNPE-caged Luciferin

The cell permeable DMNPE-caged Luciferin is as a bioluminescent luciferase substrate used to measure intracellular functions since it readily crosses cell membranes. It is a D-luciferin ester analogue of luciferin.


  • High purity
  • Cell permeable: efficient luciferin delivery into intact cells even at neutral pH
  • Ideal for in vivo applications
  • Induces prolonged release of luciferin by the action of cells’ esterases
  • Allows to follow changes in gene expression in live cells
  • Suitable for in vitro experiments


Once the caged luciferin is inside the cells, active luciferin can be released by the action of endogenous intracellular esterases or by a flash of UV light. This implies:
1. A more efficient delivery of luciferin into intact living cells & improved sensitivity analysis of in vivo luciferase assays
2. A long-term measurement of luciferase activity since hydrolysis by esterases allows a continuous supply of active Luciferin
DMNPE-caged luciferin appears a good alternative to D-Luciferin classically used to measure luciferase activity in live cells. Indeed, the difficulty to deliver D-Luciferin into living cells renders in vivo quantification limited to a certain extent- for example, permeability issues at neurtral pH.


Shipped at room temperature.
Store at -20°C and protect from light.

Formula: C₂₁H₁₉N₃O₇S₂
MW: 489.52 g/mol
Storage Temperature: Freezer
CAS Number: 223920-67-0
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