Anti-CGA (HCG-alpha) & CGB (HCG-beta) Mouse Monoclonal Antibody (CF405S) [clone: HCGab/52]

Supplier: Biotium

BNC040052-100 BNC040052-500
75950-326EA 205.77 USD
75950-326 75950-328
Anti-CGA (HCG-alpha) & CGB (HCG-beta) Mouse Monoclonal Antibody (CF405S) [clone: HCGab/52]
Antibodies
This MAb is a very special because it reacts ONLY with the intact-HCG and not with either free alpha- or free beta-chain of HCG. HCG is a glycoprotein and is composed of two non-identical, non-covalently linked polypeptide chains designated as the ? ? and ? ? subunits. The ? ? subunit is identical to that of thyroid stimulating hormone (TSH), follicle stimulating hormone (FSH), and luteinizing hormone (LH). HCG is secreted in large quantities by normal trophoblasts. It is present only in trace amounts in non-pregnant urine and sera but rises sharply during pregnancy. HCG MAb detects cells and tumors of trophoblastic origin such as choriocarcinoma. Large cell carcinoma and adenocarcinoma of the lung demonstrate anti-hCG positivity in 90% and 60% of cases respectively. 20% of lung squamous cell carcinomas are positive. HCG expression by non-trophoblastic tumors may indicate aggressive behavior.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®405S is a blue fluorescent dye (Ex/Em 404/431 nm) with superior brightness compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Type: Primary
Antigen: CGA (HCG-alpha) & CGB (HCG-beta)
Clonality: Monoclonal
Clone: Clone HCGab/52
Conjugation: CF405S
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Human
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