FREE soluble RANKL ELISA Assay Kit, Eagle Biosciences, Inc.

Supplier: Eagle Biosciences
BI-20462
103389-390EA 1412.31 USD
103389-390
FREE soluble RANKL ELISA Assay Kit, Eagle Biosciences, Inc.
Assays ELISAs
Free soluble RANKL ELISA detects free, soluble, uncomplexed human RANKL in serum or heparin plasma.

  • Dynamic Range: 0 to 2 pmol/l
  • Sensitivity: (0 pmol/l + 3 SD): 0.01 pmol/l / 0.008pmol/l
  • Incubation: 3.5 hours

RANKL, the receptor activator of nuclear factor kappa B ligand, a member of the tumor necrosis factor (TNF) family, is the main stimulatory factor for the formation of mature osteoclasts and is essential for their survival. RANKL activates its specific receptor RANK, located on osteoclasts and dendritic cells. The effects are counteracted by OPG which acts as an endogenous soluble receptor antagonist (see: BI-20403 – OPG ELISA). The major source of RANKL are osteocytes, former osteoblasts that become embedded within the mineralized bone matrix. RANKL is a ~35 kD type II transmembrane-type protein and is cleaved to release a soluble biologically active product that forms a homotrimer. RANKL and its specific receptor RANK are not only key regulators of bone remodeling but also play an essential role in immunobiology, e.g. lymph node formation, establishment of the thymic microenviroment, mammary gland development during pregnancy, bone metastasis in cancer and sex-hormone, progestin-driven breast cancer, thermoregulation, and finally in the development of type 2 diabetes mellitus.
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