Anti-IA2 ELISA, Eagle Biosciences

Supplier: Eagle Biosciences
3803
103389-284EA 1203.08 USD
103389-284
Anti-IA2 ELISA, Eagle Biosciences
Assays ELISAs
Anti-IA2 ELISA determines autoantibodies to Protein Tyrosine Phosphatase IA2 in human serum.

  • Dynamic Range: 15 - 400 IU/ml
  • Sensitivity: 0.5 IU/ml
  • Incubation: overnight

IA2, a member of the protein tyrosine phosphatases family is localized in the dense granules of pancreatic beta cells and the second defined recombinant islet cell Antigens. IA2 shares sequence identity with the islet cell Antigens 512. The higher frequency of antibodies to IA2 is explained by the presence of autoantibodies directed to the COOH terminus of IA2 which is lacking in the ICA512 molecule. IA2 autoantibodies are present in the majority of individuals with new-onset type 1 diabetes and in individuals in the pre-diabetic phase of the disease. The appearance of autoantibodies to IA2 seems to be correlated with the rapid progression to overt type 1 diabetes.
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